Single-cell Transcriptomics, Web-based Systems Pharmacology and Integrated Transcriptomics Network Analysis Identified Diagnostic Targets and Drug Candidates for Type 2 Diabetes | Bentham Science Publishers - go.shr.lc/46KIKIh

50 mg of oral #semaglutide daily was associated with body weight reduction and improved cardiometabolic risk factors in East Asian adults with overweight or #obesity, with or without type 2 #diabetes. ja.ma/4mq5iSW

New in Journal of Experimental Medicine: Vini Tiwari, PhD & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders hubs.la/Q03BkGPK0 #Neuroinflammation

Mechanotransduction in the nucleus Multiple TFs transmit mechanical forces into transcriptional regulation. Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

Autoimmune β cell destruction causes type I diabetes, but efforts to modify the immune response have yet to produce a cure. Virginia S. Shapiro & team Mayo Clinic discover expression of the enzyme ST8Sia6 in β cells prevents islet-specific autoimmune diabetes in mice:

Nature research paper: Whole-genome sequencing of 490,640 UK Biobank participants go.nature.com/45KBcTN

I had the privilege to work with several experts in T1D as part of a June 2024 international Expert Forum at ADA organized by the editors of Diabetes, Diabetes Care, and Diabetologia to write a review article on T1D heterogeneity, check it out! diabetesjournals.org/diabetes/artic…

A wearable sensor that measures multiple hormones simultaneously in sweat to provide continuous real-time metrics and dynamics of stress science.org/doi/10.1126/sc…

Excited to share our latest paper @NatureMethods We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4). nature.com/articles/s4159…

Our NEW Primer on Pleural mesothelioma is live today! By Fennell, Sekido, Baas, Husain, Curioni-Fontecedro, Lim, Opitz, Simone II, Brims &Chi-sang Wong. Check it out here: nature.com/articles/s4157…

New content online: Adipose tissue thermogenesis is not proportional to temperature bit.ly/41yRiye

A previously healthy 47-year-old woman presented to the neurology clinic with a 1-month history of worsening headaches associated with blurry vision, galactorrhea, and irregular menstrual cycles. Physical examination was notable for reduced visual acuity of 20/50 in both eyes,

Breathing polluted air increases the risk of #osteoporosis, growing evidence shows. Learn more: scim.ag/3ZVMvoS #ScienceMagArchives

Endocrine complications occur in 40–60% of survivors of cancer and include hypothalamic–pituitary disorders, dysregulation of steroid and peptide hormones, and dysregulation of bone and metabolism thelancet.com/journals/landi… #OpenAccess

HIF-independent oxygen sensing via KDM6A regulates ferroptosis dlvr.it/TMNJD5

Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation Cell Systems cell.com/cell-systems/f… Christoph Bock Lab @ CeMM & MedUni Vienna Peter Traxler

Targeting myosin II to alter the disease course of challenging disease... sciencedirect.com/science/articl…

Prevalence of Islet Autoantibodies in Adults Without Diabetes - 3.9%, which is higher than I expected. academic.oup.com/jes/article/9/…

Genetics Evaluation Outcomes From an Academic Multidisciplinary Atypical Diabetes Program academic.oup.com/jes/article/9/…

Modeling Adipokine and Insulin‐Mediated Crosstalk Between Adipocytes and Beta Cells Using Flow‐Enabled Microfluidics - Orabi - Small - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.10…