Human Body Single-Cell Atlas of 3D Genome Organization and DNA Methylation biorxiv.org/content/10.110… #biorxiv_genomic

What protects individuals from developing blood cancers? Thrilled to share my work in Vijay Sankaran lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) biorxiv.org/content/10.110…

Excited to share our exploration Nature Methods into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇

New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & George Vassiliou as described by Peggy Goodell: nature.com/articles/d4158…

Regulatory sequence ML has been widely applied to predict substitution SNP effects (to promising results!), but most teams have shied away from indels. biorxiv.org/content/10.110…

It has been unclear why cancer patients with CH have worse outcomes. Our work published NEJM uncovers that Tumor infiltrating CH (TI-CH) has a direct role in immune remodelling of the TME with implications for tumor progression & treatment response. Memorial Sloan Kettering Cancer Center The Crick

I'm thrilled to share our new #bioRxiv preprint from ⁦Junyue⁩ lab at ⁦Rockefeller University⁩! We present PerturbFate, a high-throughput single-cell CRISPR platform profiling nascent/pre-existing RNA, steady-state RNA & chromatin accessibility. biorxiv.org/content/10.110…

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at Centre for Genomic Regulation (CRG) nature.com/articles/s4158…

Finally out in Nature our collaboration with the Velten Lab 🥰 Enjoy the reading! nature.com/articles/s4158…

Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today Cell Stem Cell !! An amazing collaboration with AK Eisfeld & Elli Papaemmanuil, PhD & Dan Landau !!! Driven by the impressive Maria Sirenko

Congratulations to this powerhouse of a team!!! leukemia science at its best!!! #hemepath #AMLsm aficionados please dig in and enjoy!! Link to full PDF: sciencedirect.com/science/articl…

Please check out the full tweetorial!

Phenotyping recurrent genomic architectures. Led by Maria Sirenko Soobeom Lee & Z. Sun, our study Cell Stem Cell shows how patterns of co-mutations shape lineage composition + drive diverse cellular programs in AML. Awesome collaboration with Dan Landau Iannis Aifantis++🧵⬇️

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in Nature Genetics 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

The FUTURE is NOW! 🚨 Whole-Transcriptome Spatial Genomics with OUT-OF-THE-BOX analysis starring Helena Lucia Crowell. 🔬 Spatial genomics has now reached FULL-transcriptome resolution, enabling spatially resolved single-cell analysis at million cell scale. With this, we’re rethinking how

🧵1/ Thrilled to share our lab’s first paper, just out in @BloodCancerDisc led by the talented Cuijuan We uncovered an isoform-specific RUNX1C–BTG2 axis that drives chemoresistance in AML. 👉 aacrjournals.org/bloodcancerdis…

I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic variant embeddings to downstream tasks in human genetics. This work was led by the amazing Divyanshi Srivastava! biorxiv.org/content/10.110…

The IICD SRP is wrapping up soon! Yesterday, our interns presented their research at the Columbia CUPP Symposium. Huge thanks for organizing an incredible event! cc: Lingting Shi Elham Azizi s. Khanh N. Dinh Darcy Peterka Genevera Allen Jose L. McFaline-Figueroa Soobeom Lee