Is there a reasonable approach with the best benefit/investment ratio when trying to understand and solve a disease from the ground up? Does it make sense to start with genetics, proteomics or directly focusing on symptomatic tissue? @EJPRareDiseases #molecularbiology

Today we announced the initiation of our Ph2a trial of LYT-300 (oral #allopregnanolone) for the potential treatment of #anxiety disorders. LYT-300 is derived from our Glyph platform, which enables the oral administration of a range of therapeutics bit.ly/3NlGaNi

MS patients suffer from anhedonia due to neuroinflammation. Simon Breidert M_K @JacobSchapira5 journals.sagepub.com/doi/full/10.11…

PSSD Scandinavia M_K @JacobSchapira5 That's what my bet was. My bet is all chronic neuroinflammatory diseases show signs of depression/anhedonia, reduction of libido and potentially insomnia due to SRD5A2 methylation triggered by TNF alpha and other proinflammatory cytokines.

first time since the marketing of isotretinoin in 1984, MHRA official report scientific studies detailing the complex biochemical mechanisms of this molecule, proof being the urgent need for new new studies in-depth basic research. gov.uk/government/pub…

Loading... Simon Breidert cos.io/open-science osf.io researchhub.com

State of the knowledge about the side effects of Roaccutane(#isotretinoin): review of the scientific literature -Authors : many contributors, past, present, and future, -Opensource -Year : since 2005, to complete, correct, and enrich… cjoint.com/doc/23_06/MFzx…

Simon Breidert 100% agreed. This is why an extensive literature review is the heart of every good thesis that gets published.

What research tool is the best for getting the best understanding of a the pathomechanism of a disease?

Great and easy to understand post by Dr. Michael Ruscio, DC on gut dysbiosis and neuroinflammation. drruscio.com/neuroinflammat… I would like to add that fasting and caloric restriction is also effective for dampening inflammation. cell.com/cell/fulltext/…

"WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome" pnas.org/doi/10.1073/pn… Induction of ER stress could play a role in several diseases that include fatigue. MEcfs together Dt. Ges. für ME/CFS #MECFS