As amyloid and tau pathology accumulate during the 10-20 year pre-clinical phase of Alzheimer disease, the brain amazingly compensates despite progressive synaptic dysfunction and neuronal death. By the time that compensatory mechanisms fail and symptoms first become evident,

A new The Swedish BioFINDER study paper in collaboration with WRAP has been published in Brain ! academic.oup.com/brain/advance-… Find our key findings 👇

6/🙏 Thanks to all co-authors Oskar Hansson, Jake Vogel, @alexa_pichetb, RikOssenkoppele, Sebastian Palmqvist, Erik Stomrud, Ruben Smith, Jakob Seidlitz, Richard Bethlehem, Nicholas Ashton, and all not on X.

Why academia is sleepwalking into self-destruction. My editorial Brain If you agree with the sentiments please RT. It's important for all our sakes to stop the madness academic.oup.com/brain/issue/14…

New manuscript alert! Can blood-based biomarkers measured on a fully automated platform accurately identify Alzheimer’s disease (AD) pathology?🩸 Our new multi-cohort study has now been published in Nature Medicine: nature.com/articles/s4159…. A thread🧵

A big thank you to amazing authors! Sebastian Palmqvist Noëlle Warmenhoven Federica Anastasi Nicholas Ashton Oskar Hansson BioFINDER HMar Research Institute Fundación Pasqual Maragall Barcelonaβeta Brain Research Center Göteborgs universitet / University of Gothenburg Lund University Brescia University & the patients who made this possible! 🙌

p-Tau217 is a breakthrough blood test that can accurately predict and may help prevent Alzheimer's disease. erictopol.substack.com/p/the-breakthr… Here's the rundown on it. Free, open-access.

Among 1,767 patients in 5 centers, a fully automated blood test showed high accuracy for Alzheimer’s pathology in secondary and primary care using a predefined cutoff. nature.com/articles/s4159…

Our comments on the new #blood tests for #Alzheimers #disease which are increasingly improving and becoming applicable to clinical use. We should use them but use them in the correct way. nature.com/articles/d4158…

A new, simpler and cheaper analytical method for #Alzheimers disease could help bring #blood tests into the #healthcare system globally, according to a new study led by Sebastian Palmqvist, Oskar Hansson and Noëlle Warmenhoven from 🇸🇪 Lund University. dlvr.it/TKH96w

Immunoassays for plasma p-tau217 perform as well as FDA-approved tests for CSF markers. Adding other markers could improve accuracy even more. @LundU Göteborgs universitet / University of Gothenburg 東京大学 | UTokyo Dr. Anna Mammel ow.ly/htUm50VGu7I

‼️New preprint! We are happy to share our latest work led by Toomas Erik Anijärv 🇪🇪 investigating why tau pathology in Alzheimer’s disease (AD) often accumulates more in one hemisphere of the brain than the other. Check out🔗biorxiv.org/content/10.110… or dive into the details below👇

🚨New paper in Alzheimer's & Dementia! We investigate whether p-tau immuno-assays selectively quantifying low-molecular-weight (LMW) tau (CNS) are more specific for tau changes in AD vs ALS than assays not differentiating between LMW and high-MW (PNS) tau👇pmc.ncbi.nlm.nih.gov/articles/PMC12…

Come check out our posters today at #AIC2025!

🚨Publication alert: This study led by Anika Wuestefeld, PhD aims to provide a more granular understanding of how tau pathology leads to specific cognitive decline in Alzheimer's disease. 🧠 Out now in Alzheimer’s & Dementia! Read it here: doi.org/10.1002/alz.70… 🧵👇

🚨New publication in Nature Aging🚨 Co-led between Laia Montoliu-Gaya and Gemma Salvadó. We measured several tau peptides in blood and assess their different relationships with Alzheimer’s disease stages. nature.com/articles/s4358… 🧵

🚨New paper alert! Our study led by Toomas Erik Anijärv 🇪🇪 investigated why some individuals with Alzheimer’s disease (AD) develop hemispheric asymmetry in tau pathology and what drives this phenomenon. Out now in Nature Communications! 🔗Full article: doi.org/10.1038/s41467… A thread🧵👇

🚨New publication in Nature Medicine! In this study, we demonstrate that a brief, self-administered cognitive test battery can reliably identify individuals with cognitive impairment in a primary care setting. Details: linkedin.com/feed/update/ur… Full paper: nature.com/articles/s4159…

The study was led by PhD students Pontus Tideman and Linda Karlsson. Thank you also to all co-authors: Ruben Smith Niklas Mattsson-Carlgren Erik Stomrud Sebastian Palmqvist Oskar Hansson and those not on X.

🚨Paper alert🚨 New publication in JAMA Neurology led by Gemma Salvadó. In a multicentric study, we examined the clinical utility to assess preclinical #Alzheimer's disease in cognitively unimpaired individuals. jamanetwork.com/journals/jaman… A 🧵...