🚨 Hot off the press! #WeekendReading 👉 Delighted to share our latest paper on "Tumor-agnostic drug development in dMMR/MSI-H solid tumors" just published in Trends in Cancer Cell Press ! 👉dMMR/MSI-H = Perfect marriage of genomics & #immunotherapy fields #PrecisionMedicine

Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas biorxiv.org/content/10.110…

💥BIG PAPER ALERT💥 So excited to share our latest, out now nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s4158…

Local registration for the 2024 round of my Statistical Rethinking course has begun. I'll open up registration on Sunday 3 December. Registration link will appear on the course github page: github.com/rmcelreath/sta…

Newest GLASS paper online! The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen aacrjournals.org/cancerres/arti… congrats to Houtan Noushmehr

Incredible work by the team in describing the clinical features, cancer spectrum, and biology of CMMRD. Check it out!

📢 Just published in JCO! What is the optimal chemotherapy for oligodendroglioma patients? Our study using data from the national prospective cohort POLA found better PFS and OS outcomes with first-line RT/PCV compared to RT/TMZ ascopubs.org/doi/10.1200/JC…

Thrilled to share our discovery of novel long-deletion #signatures—powerful markers for tracking #MMRd #CancerEvolution, even in low-pass (~0.1X) FFPE samples with low tumour content, using our tool #MILO. Check out our preprint for the full story biorxiv.org/content/10.110… (1/8)

David Ohayon from the Center for Integrative Biology (Toulouse) has an important recommendation here at #Lazaret #GCC2024: Stop using Olig2 to label oligodendrocyte: specific astrocyte subpopulations are Olig2-positive!

#EANO2024 Congratulations to Alberto Picca for receiving the EANO Young Investigator Travel Scholarship! Join him at the Keynote Session: Gliomas with pleomorphic & pseudopapillary features […] 📅 SUN, Oct 20 🕙 10:10-10:20 📍 Lomond Auditorium

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation biorxiv.org/content/10.110…

First of a series of papers from the @NCIHTAN is out in nature this morning. Tumour evolution and microenvironment interactions in 2D and 3D space nature.com/articles/s4158…

Happy to share our accepted manuscript, led by Franziska Ippen, on hemizygous CDKN2A/B deletions in IDH-mutant gliomas. Based on our manual assessment, we found no significant impact on survival in our cohort. academic.oup.com/neuro-oncology…

According to dynamical systems, psychiatric disorders can be seen as energy landscapes with peaks and valleys. OCD has deep valleys where neural activity gets stuck, while schizophrenia has shallow valleys that let neural activity roam too freely, connecting unrelated ideas.

Out in Science 🧬! Using FFPE-CUTAC to profile RNAPII, we discovered that histone gene hypertranscription predicts rapid cancer recurrence and is linked to chromosome losses in meningioma and breast cancer. One more step to unraveling cancer progression! science.org/doi/10.1126/sc…