Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to #obesity and cardiometabolic risk JCI insight insight.jci.org/articles/view/…

#Hypothalamic #obesity: from basic mechanisms to clinical perspectives thelancet.com/journals/landi… #hyperphagia

Social isolation is toxic to the brain.

"ChatGPT is likely now to be the most widely used mental health tool in the world".

Objects are more memorable when people encounter them while feeling positive emotions than while feeling negative ones go.nature.com/44reora

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate go.nature.com/44jPqvg

Diagnosing clinical obesity #medx #TICMED25 #obesity #TIC2025

The liver converts fructose into lipids to fuel tumours. nature #TIC2025 "Fructose supplementation increases circulating nutrients such as LPCs, which can enhance tumour growth through a cell non-autonomous mechanism." #Nutrition #nutrients #fructose nature.com/articles/s4158…

Proud to share Jose M. Adrover’s (new PI The Francis Crick Institute) paper: As a postdoc (Cold Spring Harbor Laboratory/Johns Hopkins Medicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis. nature.com/articles/s4158… @JHU_BDP nature

In our #MostRead: Prevalence of #clinical #obesity versus #BMI-defined obesity among US adults: a cohort study thelancet.com/journals/landi… #FREE to read

Multi-parameter spectral flow cytometry panel for immune phenotyping of murine B and T cell responses biorxiv.org/content/10.110… Hedda Wardemann

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in Nature Metabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n

The source of dietary fat influences anti-tumour immunity in obese mice go.nature.com/4o2w4CJ

Personalized molecular signatures of insulin resistance and type 2 diabetes: Cell cell.com/cell/fulltext/…

International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity - The Lancet Diabetes & Endocrinology thelancet.com/journals/landi…

New options for treating #obesity: In a recent Phase II #clinicaltrial, YSM's Ania M. Jastreboff, MD, PhD and colleagues report a once-monthly injection of maridebart cafraglutide (#MariTide) helped patients with obesity lose 20% of their body #weight in one year: bit.ly/46neAuu

ACLY inhibition promotes tumour immunity and suppresses liver cancer nature.com/articles/s4158…

Writing is thinking. Don't let AI do it all.

Replenishing the brain’s natural stores of lithium can protect against and even reverse Alzheimer’s disease go.nature.com/4mt8jSz

Tissue immunity meets biological sex differences - context is important in the immune system. Another of my reading recommendations during a trip to International Union of Immunological Societies Congress. From Sonia Sharma, Alicia Gibbons and Erica OllmannSaphire in Science Magazine buff.ly/XPN0Tpb