Phase separation of SHP2E76K promotes malignant transformation of mesenchymal stem cells by activating mitochondrial complexes: buff.ly/4df0bRO

#Oncology #StemCells

OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma: buff.ly/3wd4lZK

Columbia University
#Oncology

Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP: buff.ly/4dcP0sQ

Dr Avnika Ruparelia Pete Currie Centre for Muscle Research
#MuscleBiology

In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets: buff.ly/3w1q1Ip

Carver College of Medicine
#Pulmonology #Therapeutics

#Cover :Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with #COVID_19 : buff.ly/3Qwbcon
Image:proinflammatory microglia, with the image rotated around a central axis to create a stellate, fractal-like pattern
Benjamin D. Singer

#ClinicalMedicine :
Molecular subtyping improves breast cancer diagnosis in the Copenhagen Breast Cancer Genomics Study: buff.ly/49GEeIz

#Oncology

#ClinicalMedicine :
Diagnosis of malignant body fluids via cancer-universal methylation in cell-free DNA: buff.ly/443fPvw

#Genetics #Oncology

Differentially disrupted spinal cord and muscle energy metabolism in spinal and bulbar muscular atrophy: buff.ly/3JnnV8A
Thomas Jefferson University
#Genetics #Neuroscience

HIV-1–infected T cell clones are shared across cerebrospinal fluid and blood during ART: buff.ly/3Josqjy

Shelli Farhadian Yale School of Medicine
#AIDS #HIV #Immunology

Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish: buff.ly/3Jg6nLP
Mayo Clinic
#Cardiology #Genetics

A urine-based test that detects tumor DNA fragments could offer early reliable screening for head and #neckCancer @umich @JCI_Insight medicalxpress.com/news/2024-04-u…

#ClinicalMedicine :
A complement C4–derived glycopeptide is a biomarker for PMM2-CDG: buff.ly/3VUV3w4
Akhilesh Pandey Lab Morava Eva Mayo Clinic Icahn School of Medicine at Mount Sinai
#Genetics #Metabolism

Alkali injury–induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation: buff.ly/3xCJboi

#Immunology #Ophthalmology

Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS: buff.ly/4ayHPcZ
NIAID News
#ClinicalMedicine #AIDS #HIV
#ClinicalTrials

Activation of the IKK2/NF-κB pathway in VSMCs inhibits calcified vascular stiffness in CKD: buff.ly/49xft1f
CU Anschutz Medical Campus
#VascularBiology

Single-cell molecular signature of pathogenic T helper subsets in type 2–associated disorders in humans: buff.ly/43ZHo9a

Pedro Gazzinelli Guimaraes NIAID News
#Immunology #InfectiousDisease

Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron: buff.ly/4aqLbPd

#ClinicalMedicine
#COVID_19 #Immunology

Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment: buff.ly/3TPArml
UC San Francisco
#Immunology #Oncology

Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance: buff.ly/43UIOkX

Nadejda Bozadjieva Kramer, PhD Randy J. Seeley, Ph.D. Michigan Medicine
#Gastroenterology #Metabolism

Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation: buff.ly/3vVffmN

Charaf Benarafa Universität Bern
#COVID_19 #Inflammation