Join us next week on March 11 for our 2025 OpenScope Data Release webinar. 🔭🧠 Attendees will learn about the experimental designs of the 2024 projects including studies related to psychedelics and visual perception. 🔗 alleninstitute.org/events/2025-op… #OpenScience

A subcortical switchboard for perseverative, exploratory and disengaged states nature.com/articles/s4158…

Big name, top facilities, and allegations of abusive behavior & toxic environments. DW and DER SPIEGEL investigated the claims against the Max Planck Society and spoke to over 30 young scientists. The findings suggest a systemic failure of accountability. p.dw.com/p/4rhZH

Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁 Led by Ling-Xiao Shao and Clara Liao Funded by NIH National Institute of Mental Health (NIMH) 📄Read in nature - nature.com/articles/s4158… 1/12

The human consciousness signal has been identified. Groundbreaking Science Magazine study convincingly showed that the activity of certain nuclei in the human thalamus are needed to consciously perceive what we see.

These look like really solid results indicating that psychedelics are not acting like antidepressants, contrary to what many might think biorxiv.org/content/10.110…

How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614 50+ neuroscientists distributed across the world worked together to create this unique community project.

arxiv.org/abs/2504.09614

I like OpenAI’s mission of 'ensure that artificial general intelligence benefits all of humanity”, and I’d like to stop them from completely gutting it. I’ve signed on to a new letter to Rob Bonta & Attorney General Kathy Jennings asking them to halt the restructuring. (1/2)

IMO an over-reaction bc ketamine has many uses, but we are about 5 years from a similar backlash in the US if we continue mailing ketamine and injection needles to anyone who asks nicely

As Eran Mukamel and Yu point out, #methodsmatter. They are spot on here: nature.com/articles/s4158…

Our work with Pablo Tano , HyungGoo Kim Athar N Malik, MD, PhD Alexandre Pouget and Nao Uchida exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in nature nature.com/articles/s4158…

Locus coeruleus activation “resets” hippocampal event representations and separates adjacent memories cell.com/neuron/abstrac…

BREAKING: Apple just proved AI "reasoning" models like Claude, DeepSeek-R1, and o3-mini don't actually reason at all. They just memorize patterns really well. Here's what Apple discovered: (hint: we're not as close to AGI as the hype suggests)

Out today in nature: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables. nature.com/articles/s4158…

Inspired by Michael Eisen I've begun an experiment in open science. We are sharing our ongoing work on psychedelic signaling here: open.substack.com/pub/zendudest/… I've decided to make this 'open' as the experiment are of immediate interest to the field and I'll write them up later.

Poster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics

"I use AI in a separate window. I don't enjoy Cursor or Windsurf, I can literally feel competence draining out of my fingers." DHH, the legendary programmer and creator of Ruby on Rails has the most beautiful and philosophical idea about what AI takes away from programmers.

New preprint from collaboration with SchafferNishimuraLab - 2p imaging of psilocybin's effects on neurovascular coupling 🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This affects how we should interpret fMRI BOLD studies of #psychedelics‼️