I would like to share our recent work on the risk of clozapine induced agranulocytosis over the entire course of treatment

100%, never seen any robust evidence for psychosis per se being neurotoxic (although I do think a priori reasonable to think that, not working, not having any social interactions etc. is not going to be great for your gray matter over time)

‼️ New ‼️ paper out in Neuropsychopharmacology from Gemma Modinos Nick Livingston & team:

Diazepam normalizes hippocampal hyperperfusion in people at clinical high risk for psychosis, implicating medial temporal GABAergic dysfunction in⬆️vulnerability for psychosis

nature.com/articles/s4138…

Come help develop new treatments for psychosis, last day to apply!!

Find out more about GALENOS - the new resource for research into anxiety, depression & psychosis.

These living systematic reviews, funded by Wellcome, will accelerate #MentalHealth research.

Join the Global launch events:

For Europe, USA & Africa: eventbrite.co.uk/e/galenos-laun…

🚨 Veeeery excited that my 1st paper from my PhD has just been published in Schizophrenia Bulletin! 🎉Using electronic health record data from 567 individuals at CHR for psychosis to look at associations between benzodiazepine exposure and clinical outcomes 💊 doi.org/10.1093/schbul…

Fantastic paper - the cognition field will not progress by relying on quantitative data alone and with the voice of lived experience missing. Thanks for this important review and call for us to keep striving to do better.

NHS England seems determined to destroy the clinical academic training pathway.

We hear a lot about biases in AI, but can it be a tool to tackle systemic inequality? Those able to navigate hoops to access psychotherapy tend to be more privileged. Work in Nature Medicine shows an AI chatbot ⬆️ ⬆️ referrals for minority groups nature.com/articles/s4159…

Really important thread about the importance of NHS support for clinical academic training and why it needs to go beyond lip service. Should matter to all doctors.

New JAMA Psych paper on schizophrenia cases in UK biobank. Very nice paper but always find these polygenic risk score plots a bit sobering orca.cardiff.ac.uk/id/eprint/1656…

💊💪Oestrogen & raloxifene antipsychotic augmentation in females with schizophrenia improves symptoms: meta-analysis of 13 double blinded RCTs (n=1143), mean reduction in PANSS of ~7 vs. placebo at 4-8 weeks, spread across all symptom dimensions pubmed.ncbi.nlm.nih.gov/36585771/

The two most important questions, that nobody seems brave enough to ask in public, are these: 1. To what extent do many cases of long COVID represent expression of a functional illness? and 2. How effective are treatment approaches based on conceptualising the illness as such?

The 2nd paper from my PhD has now been published as #openaccess in Molecular Psychiatry. Another big collective effort involving Forensic Research Group Andreia C. Pereira Julia Griem and others

Full version @molpsychiarty: shorturl.at/huzZ8

1/5

Cutting edge techniques creating organoids from post-mortem tissue in schizophrenia. But with only N=4 in each group is there a danger the field will become filled with false positives?ajp.psychiatryonline.org/doi/10.1176/ap…

💊The swiss army knife of drugs? An overview of potential therapeutic uses of semaglutude beyond diabetes/obesity. With such high rates of multi-morbidity in people with SMI, is GLP1RA prescription something we will see more of in psychiatric clinics?
link.springer.com/article/10.100…

🔬 New study in 672,823 individuals links mental disorders to later cardiometabolic complications.
Importantly, general liability to psychopathology rather than specific diagnoses identified as a key risk factor. Transdiagnostic approaches may help

ajp.psychiatryonline.org/doi/10.1176/ap…

🤔Do RCT results reflect real-world outcomes in the pharmacological management of schizophrenia? 📜Great paper by Orestis Efthimiou and colleagues comparing RCT and observational (‘real world’) data in antipsychotic treatment of schizophrenia, a short 🧵 pubmed.ncbi.nlm.nih.gov/38215784/ 1/5

🌟 New meta to identify key elements of CBT for Insomnia. Effective elements identified:
🧠Cognitive Restructuring
🕰️🛏️Sleep Restriction & Stimulus Control
🤝In-Person Delivery
🚫 But perhaps most interestingly relaxation was not helpful jamanetwork.com/journals/jamap…