💊💪Oestrogen & raloxifene antipsychotic augmentation in females with schizophrenia improves symptoms: meta-analysis of 13 double blinded RCTs (n=1143), mean reduction in PANSS of ~7 vs. placebo at 4-8 weeks, spread across all symptom dimensions pubmed.ncbi.nlm.nih.gov/36585771/

Cutting edge techniques creating organoids from post-mortem tissue in schizophrenia. But with only N=4 in each group is there a danger the field will become filled with false positives?ajp.psychiatryonline.org/doi/10.1176/ap…

Bigger isn't always better. Higher doses of stimulants have minimal benefits but significantly greater risks than doses within the licensed range

Phosphodiesterase type 5 inhibitor prescription associated with 18% reduction in Alzheimer's disease risk in UK electronic health record study of 270k men. Effect larger in those with more prescriptions. Something to think long and hard about 🤔neurology.org/doi/10.1212/WN…

💊⏰🫀💥Longer cumulative duration of ADHD medication use associated with increased risk of CVD, especially hypertension & arterial disease: large-scale case control study using Swedish registry data pubmed.ncbi.nlm.nih.gov/37991787/

We hear a lot about biases in AI, but can it be a tool to tackle systemic inequality? Those able to navigate hoops to access psychotherapy tend to be more privileged. Work in Nature Medicine shows an AI chatbot ⬆️ ⬆️ referrals for minority groups nature.com/articles/s4159…

Psymatik's opinion of antidepressant efficacy psymatik.com

Outputs a heat map based on the input from the Psymatik interface, showing side effect profiles of interest PLUS how efficacious the drugs are

#BAP2023

Also, a fascinating talk from Rob_McCutcheon this morning - the typical/atypical categorisation of antipsychotics is too simplistic.
Looking forward to using the Psymatik tool to compare different receptor targets and AP SEs in clinical practice #RCPsychIC

Want to learn how to supercharge your psych prescribing? Come to our #RCPsychIC symposium at 10am today to learn about Psymatik and latest NMA side-effect data with Rob_McCutcheon Anneka Tomlinson

Psymatik (Psymatik), a new web tool created by Toby Pillinger and colleagues, streamlines sorting through antidepressant and antipsychotics side-effects. hcplive.com/view/psymatik-…

#Psymatik

Psymatik Toby Pillinger @TheLancetPsych Looking forward to reading the paper

The Psymatik interface allows you to select antipsychotic/antidepressant, then 'optimise treatment' by selecting side effects and their relative importance for the patient in question for as many side effects as you like

#BAP2023

Coming out soon in Lancet Psychiatry, a digital tool called Psymatik to create individualised league tables for patients using a systematic review of side effects of monotherapy of antipsychotics/antidepressants

#BAP2023