💤Researchers found that prescription stimulants for ADHD act on brain networks that control wakefulness and reward, but not attention as previously thought. The study suggests that stimulants and additional sleep affect the brain in similar ways, and that getting enough sleep

We recently reconceptualized ADHD as a circadian rhythm disorder.

Circadian disruption has long been linked to mental health disorders. We now have more evidence that the link may be causal. A longitudinal study found circadian disruption directly preceded mood symptoms, with a causal signal in 66.7% of MDD and 85.7% of bipolar I patients.

Every time you replace “I’m overwhelmed” with “I need to decide what matters most and go slow,” your brain stops firing alarm signals and starts organizing information again.

A review of the new trial results (below) along with all the other evidence and conclude it's time to move to AI-support for all mammography (with no cost to patients) erictopol.substack.com/p/why-all-mamm…

#LifestyleMedicine🍏

I built an app that lets you talk to statues. Naturally, I took it for a spin at the British Museum. Full conversations in the thread.

A lot of people are sharing this new meta-analysis as proof that “intermittent fasting has no benefits.” I don’t think that’s what it shows. What it does show is pretty straightforward. In controlled trials (where calories are matched), IF produces weight loss similar to

#CircadianHealth #Chronobiology⏰

In case you forgot how fast gen AI is moving. Seedance 1.0 topped leaderboards in June 2025, and the previews of Seedance 2.0 are blowing us away. Other video model providers like Kling and Grok aren’t far behind – and we expect there’s more to come from Sora at OpenAI and Veo

Revolution [a complete circle or turn round a centralpoint, axis] [to roll back, to bring back]

New nature The brains of Super Agers produce more neurons than people some 40 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills nature.com/articles/s4158…

Striking image from the new Anthropic labor market impact report.

#LifestyleMedicine 🍎🔥🔥

This is a #Classic👌✨

A “computer” used to be a job title. Then a computer became a thing humans used. Now a computer is becoming a thing computers use.

5 million deaths a year globally are attributed to lack of physical activity. Many countries have set policies to promote physical activity but never implemented them. No improvement in >20 years! 3 new papers Nature Medicine naturehealth nature.com/articles/s4159…

You learn by doing. There’s no other way.

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