Congrats Qin and Jennifer!!!👏👏👏

Team work from Locher Lab and Henning Stahlberg Dongchun. Ni Julia Kowal: Structures of ABCG2 under turnover condition show the key conformational changes for drug transport.

📢Very happy to share the first publication of our lab at UNIGE UNIGE_en published in Nature nature. This has been a highly collaborative effort. rdcu.be/cpk5v We identified surprising, new aspects of the cell cycle regulator separase using cryoEM. A short thread🧵

A recent study (Locher lab in collaboration with the Stahlberg group, University of Basel) determined the turnover states structures of ABCG2 which reveal key conformational changes that are essential for substrate recognition and translocation. More: biol.ethz.ch/en/news-and-ev…

We are happy to share our latest article, now available online PNASNews. Check out our #cryoEM structures of the #membranetransporter ABCB4 and more on how the transporter translocates phosphatidylcholine here: pnas.org/content/118/33… Congrats to Kamil Nosol and all the authors!

Happy to share our latest study of adenylyl cyclase 9. With collaboration with Plückthun lab, we developed a DARPin C4, which specifically activates AC9. We also captured the second MANT-GTP binding pose. Thanks Dessauer and Bondar lab and all authors. biorxiv.org/content/10.110…

In our latest preprint, we use nanobodies to study and highjack the human vitamin B12 uptake route. Congrats to Joël Bloch and all authors! biorxiv.org/content/10.110…

Check out our universal anti-nanobody Fab *NabFab* for the convenient repurposing of nanobodies as fiducial marks in cryo-EM! biorxiv.org/content/10.110… Congrats to Joël Bloch, Somnath Mukherjee, and all authors! Fantastic collaboration with Tony Kossiakoff at The University of Chicago!

We are happy to share our latest article, "Structure of the human cholesterol transporter ABCG1" in Journal of Molecular Biology . Congrats to @LigaSkarda and all the authors!! sciencedirect.com/science/articl…

“I was always fascinated by drug components, how they are obtained and how they develop their effect” - Meet Jennifer Müller, @NCCR_TransCure PhD student ETH Zürich, in the NCCRWomen video of today: youtu.be/0jZKuogVn38

Super nice and helpful supervisor, highly recommended!

Many thanks to the great support of NCCR_TransCure @NCCR_TransCure and Locher Lab Locher Lab. Congratulations to Jonai Pujol Gimenez at Hediger Group. Glad to have the opportunity to work on exciting NCCR TransCure projects! Photo credit to Ana

Hard work from Chao's fruitful PhD. Proud of you♥️! Congratulations to Chao Qi and all co-authors!

I am happy to share our Connexin43 structure determined by #CryoEM at 2.26Å. The structure is captured in a "closed" state. The #MD simulation shows NTD could be open after applying trans-junctional voltage. A nice collaboration with Silvia Acosta-Gutierrez Gervasio's Research Group (Protein Dynamics)

We are very happy to share our latest article "Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase" in Nature Communications. nature.com/articles/s4146…

Fruitful collaborations with Tajkhorshid lab at University of Illinois. ❤️