New DCI-Lausanne flyer, many thanks to Margot Margot Riggi

Thrilled to share our first preprint: Mechanism of multimodal substrate translocation in Pgp. Great team effort with twitterless QZhang and IUrbatsch. Very proud of my student @Thgeweri and Dovile Januliene and @Krparey! #CryoEM Uni Osnabrück Max Planck Institute of Biophysics biorxiv.org/content/10.110…

Postdoc or senior scientist position available in our group, to develop methods in cryo-EM, using a Cold-FEG Titan Krios with RF-cavity single-electron gun, Cs-probe corrector and Falcon4i & hybrid pixel detector. Contact me offline for more info, or visit lbem.epfl.ch

"Knowledge is our best common good." Happy 80th birthday to 2017 chemistry laureate Jacques Dubochet! #NobelPrize

The Nuclear Pore Complex (NPC) in Science: It's been quite a journey and we (Pietro Fontana, Ying Dong, Xiong Pi, Alex Tong, @pietrofn, @Ying70337209, @Sampich4) are so glad to be part of the amazing progress on NPC structures! dropbox.com/s/rlvq19wd3q1u…, science.org/doi/10.1126/sc…

Our last explorations with MaSIF and surface fingerprints for the computational design of de novo protein-protein interactions ! A lot of hard work from Pablo, @AKVanHall, Sarah, Andrea, Anthony, Michael Bronstein and collaborators biorxiv.org/content/10.110…

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver | Cell Research nature.com/articles/s4142…

Cryo-EM structures and binding of mouse ACE2 to SARS-CoV-2 variants of concern biorxiv.org/cgi/content/sh… #biorxiv_immuno

It’s live, a short report! Dongchun. Ni and I had the chance to prepare a few mouse ACE2 complexes with various variants of concern to observe structurally by cryoEM the mutations on the Spike protein that allow it to infect mice more efficiently. Comments welcome! 🧵/1

New preprint on surveillance of coronaviruses in UK bats. Out of 48 samples from 16 bat species, we produced 9 complete high-quality genomes of coronaviruses representing 4 viral species with two having not been described before. 1/ biorxiv.org/content/10.110…

Dongchun. Ni Henning Stahlberg you can read the News & Views by Rish & Fu covering the newly identified type III CRISPR–Cas system Craspase nature.com/articles/s4159…

almost as beautiful as the science it represents - checks out work from Dongchun. Ni & Henning Stahlberg labs on the CRISPR-guided nuclease Cas7-11 that forms a bird-like Craspase complex with TPR-CHAT out in NatureStructMolBiol nature.com/articles/s4159…

Oh,wow....!

Our paper with Bruno Correia Pablo Gainza-Cirauqui et al on protein design using geometric deep learning is finally in @nature We show experimental results of diverse de novo designed binders nature.com/articles/s4158…

By using deep learning-generated ‘fingerprints’ to characterize millions of protein fragments, our researchers have computationally designed novel protein binders that attach seamlessly to key targets, including the SARS-CoV-2 spike protein. actu.epfl.ch/news/engineeri…

Happy to share my second corresponding author paper. Hope It's not too boring. Nevertheless, the structures are beautiful : Activation mechanism of a short argonaute-TIR prokaryotic immune system | Science Advances science.org/doi/10.1126/sc…

"We found coronaviruses in UK bats – so far the danger’s minimal but we need to know more about viruses that can spread to humans" Cedric C.S. Tan Tom Peacock Prof Francois Balloux UCL Genetics Institute Lucy van Dorp Kelvin Lau 🧬🧪💎 Dongchun. Ni The Francis Crick Institute Imperial College London theconversation.com/we-found-coron…

Wow!