Thrilled to announce our latest work. Great collaboration with @JeanYvesMasson and Jose c. Reyes. HMCES corrupts replication fork stability during base excision repair in homologous recombination deficient cells biorxiv.org/content/10.110…

Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers! nature.com/articles/s4146…

How to write a scientific paper in four slides:⬇️ A simple guide by Dr. Andrew M. Ibrahim MD, MSc.  Full guide: surgeryredesign.com/s/WritingForIm…

Check out our latest study on the DNA polymerase theta (Polθ), a precision oncology target for HDR-deficient cancers. Our work uncovers the inhibitory mechanism of a potent Polθ inhibitor using cryoEM, accelerating rational drug development strategies: rdcu.be/dQXqB

Just saw this permanent iodine brachytherapy paper for inoperable pancreas ca and it's really amazing. 20x20 template implant into the pancreas using lidocaine & breath hold. The liver and bowel could be penetrated during seed implantation if necessary. PMID: 35494180 #radonc

Online Now: Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells dlvr.it/TCjSGV

Humans are unreliable models of mouse disease: Cell cell.com/cell/fulltext/…

Bispecific antibodies (bsAbs) allow therapeutic applications that cannot be achieved using conventional antibodies. There are 14 bsAbs approved: 11 for cancer & 3 for non-oncology indications. This review summarizes this very active field, including bsAb signaling pathway

This is a nice summary of the mechanisms of action of various KRAS inhibitors from Adrienne Cox & Channing Der in their Science Magazine perspective.

My sister in law just reminded me of the event that helped turn me from internal medicine to anaesthesia. Being on scene without the skills or equipment, with more and more critically injured people being brought out remains with me for ever.

Recent Data of #Theranostics published in the The Lancet: LuPSMA therapy can improve PFS of patients with metastatic prostate cancer before trying chemotherapy or also as a booster to chemotherapy. Kudos to the trialists! doi.org/10.1016/S1470-… doi.org/10.1016/S0140-…

📢 Super excited to share our new study Nature Medicine on developing and validating an explainable graph-based foundation model for drug repurposing, designed specially for rare diseases, which collectively affect 300 million patients globally! 🧵1/10

Learning about the process of ferroptosis. Any potential to link to iron oxide for selective targeting? Above my knowledge level, but it makes me curious 🤔 #radbio #ASTRO24

Power and Sample Size Calculator powercalc.ca via Emil Hodzic-Santor & Michael Fralick et al

Thirty years ago, the late great 🇬🇧 statistician Douglas Altman wrote what would go on to become one of the most highly cited editorials in medicine: "The scandal of poor medical research" If he were alive today, I suspect he'd feel things are even worse bmj.com/content/308/69…

Tony Blair recounts a ridiculous tie design procurement process for an EU summit (featuring an Italian accent). Not sure any frontline UK politician today could carry a story like that.

How to prepare a high-quality manuscript #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science

🫁 SBRT has forever changed lung cancer treatment. With sub-millimeter accuracy, we now treat and even cure lung cancer in a single session. There is zero downtime with this treatment as there’s no need for anesthesia or even lidocaine. It’s just amazing. #radonc

With universities unable to afford them, clinical academics across the country are being offered redundancy. These are the people who teach our doctors and conduct ground breaking research. More must be done to support them.

This diabetic patient presented with fever, right flank pain, nausea, and vomiting. Likely diagnosis?