EGFR mutants are not a monolithic entity. In fact EGFR mutational status is heterogeneous and EGFR mutated cancers can be Dr Jekyll or Mr Hyde #AACR24 Marina Garassino

Fantastic science #AACR24 blended with the joy of a solar eclipse: art & science

Siglecs function as checkpoint receptors that contribute to cancer immune evasion. Can this lead to new IO modulators ? Cell surface glycans may be key to cancer #AACR24

The hallmarks of cancer framework provide an exceptional synthesis of carcinogenesis, but does not address complexities of cancer as a systemic disease, including tumor initiation & promotion, tumor micro- & immune macro-environments, aging, metabolism & obesity, cancer cachexia,…

Lung cancer in never-smokers represent the 5thleading cause of cancer-related mortality in the world. They are highly enriched for targetable oncogenic alterations, have low TMB, low rates of PD-L1 positivity, & lack mutational signatures. They occur almost exclusively as…

Thank you to my AACR colleagues for this humbling vote of confidence. I am honored to serve among respected leaders across the oncology space as we work to accelerate #research and further the Association’s legacy as the leading cancer research organization. #MyCompany

In-depth genomic analysis of SCLC demonstrates that treatment-naive tumors show clonal homogeneity, but chemotherapy triggers significant genetic diversity. Effective first-line treatment is crucial in SCLC, as it shapes the genomic landscape of relapse & resistance…

A noninvasive assay of cell-free DNA in plasma used to screen for colorectal cancer appears at least as effective as fecal immunochemical testing which detects human hemoglobin in stool. This liquid biopsy showed 83% sensitivity for colorectal cancer, 90% specificity for advanced…

Cancer is not a uniform disease, & neither is its treatment. I share how #MyCompany pairs our biology-first approach with the latest technology to investigate targeted options for patients who need them most in this #AmgenSponsored article: bit.ly/3uRWss7

New research introduces a noninvasive method using cfDNA methylation signatures to accurately detect #neuroendocrine #prostate #cancer , highlighting the potential of methylation profiling in personalized medicine. #PrecisionMedicine #CancerTherapy #NEPC #Genomics .…

WHO Global #Cancer Observatory just released it’s latest update. Explore incidence, mortality, & prevalence for 36 cancer types in 185 countries. You can also discover trends until 2050!. It is a fascinating website to explore. gco.iarc.fr/today/en

Delving into the future of #cancer treatment with new #ADC formats: Bispecific ADCs targeting multiple antigens, Dual-drug ADCs combining different cytotoxins, Probody-drug conjugates for enhanced tumor specificity, Immune-stimulating ADCs, Protein-degrader ADCs & other formats…

Recent trends show an increase in incidence rates for 6 of the top 10 #cancers , including breast, prostate, pancreas, as well as cervical and colorectal cancer in young adults. acsjournals.onlinelibrary.wiley.com/doi/epdf/10.33…