Wow! Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients science.sciencemag.org/content/371/65…

Let me try to explain how humans can vary genetically but race is a social construct in one tweet. Genetic differences are like the mountains. Race is like an international border. Borders have real consequences for us humans just like mountains but borders are social constructs.

I’ve had honor of teaching & mentoring many CSU students in my 20 years at UC. They are amazing. We could fill every NSF slot w/CSU grads and the only thing you’d notice is that science would be more diverse and dedicated, and half of every grad class would say Hella a lot.

Super cool! Elegant mechanism to control population size of differentiating cells.

The microbiome and human cancer science.sciencemag.org/content/371/65…

Super interesting, love the evolutionary genome structure comparison. Also, wow Fig 1! Data becomes art. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type science.sciencemag.org/content/372/65…

Wow! Very interesting! Cute smiley face nucleolus in Fig. 2B!

Excited to share out newest results. We found that the histone H3 and its copper reductase function impacts cellular iron homeostasis. Our results also suggest new therapeutic strategies for #FriedreichsAtaxia #CureFA

😱🥺🤞🏼

Check out our new paper on how the histone H3 enzyme activity ties into Fe-S cluster biology & may contribute to pathology of Friedreich’s ataxia. science.org/doi/10.1126/sc…

Jen Cheng 鄭真 and I wrote a preview on Ben Tu new cool paper on histone acetylation dynamics in response to carbon starvation in Molecular Cell Check it out! Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression cell.com/molecular-cell…

Finally published in eLife! “SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence”. We elucidated a new molecular mechanism by which cells detect and respond to pH-changes. Tweetorial (1/5): elifesciences.org/articles/70344 With Alex Holehouse @PETERSONlab

🟢 My lab is opening in May! 🎊I am #recruiting at all levels to build a diverse group. Join us in discovering new biology and engineering next-gen biotechnology! #synbio #immunology #cancer #microbes Please reach out and RT to help me spread the word! 👉 hl-lab.org

Providing trainees with higher wages and more benefits/support for childcare IS critical for making academic training possible for individuals who come for historically excluded backgrounds. And we need political and taxpayer support to accomplish this goal.

Our paper using #synbio and #MachineLearning to engineer #CARTcell signaling domains is out in Science (first release, final version is out next week). Shangying Wang Sara Capponi DrMilosSimic Hersh Bhargava Simone Bianco Damon Runyon Cancer Research Foundation science.org/doi/10.1126/sc…

Our paper, “Programming multicellular assembly with synthetic cell adhesion molecules” is now online ahead of print. nature.com/articles/s4158… @nature @ucsf Cell Design Institute @UCSF Fletcher Lab (and Andrew Harris), Faranak Fattahi Ophir Klein Josiah Gerdts Wesley McKeithan

Check out our paper Science Magazine. We engineered synthetic T cell circuits that locally produce the cytokine IL2. Specific configurations of IL2 circuits dramatically improved T cell clearance of solid tumors without systemic toxicity. Cell Design Institute @UCSF #SynBio science.org/doi/10.1126/sc…

Synthetic circuits that program new capabilities into human cells have tremendous potential to expand emerging gene and cell-based therapies. Our latest work, out today in Science Magazine, reports a platform to accelerate these developments: (1/n) science.org/doi/10.1126/sc…

Awesome!

Excited to share our latest work: L126 fine-tunes enzymatic activity of histone H3, a discovery made possible by viewing the nucleosome as an enzyme. We have a gain-of-function mutant – it’s hard to enhance an activity if it doesn’t already exist! sciencedirect.com/science/articl…