#hpbcsm #PrecisionMedicine

B-cell maturation antigen (BCMA) has emerged as a key immunotherapy target for multiple myeloma. Soluble BCMA (sBCMA) can be measured in the blood and provides insight into prognostics as well as response to therapy; even for non-secretory disease
onlinelibrary.wiley.com/doi/epdf/10.10…

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma [Mar 31, 2022] Nikolaos Trasanidis et al. Blood Journal ow.ly/vkRH50IA1i3 #mmsm #PrecisionMedicine
[THREAD]: x.com/nikos_trasan/s…

MyDRUG - Multiple Myeloma RF & Shaji Kumar themmrf.org/mydrug/ ow.ly/EPoI30mPnHT #NCT03732703 #mmsm #PrecisionMedicine
Initially, 6 arms w/ IPd +
A1 CDK Abemaciclib
B1 IDH2 Enasidenib
C1 RAS/RAF Cobimetinib
D1 FGFR3 Erdafitinib
E1 t(11;14) Venetoclax
Y1 N.A. Daratumumab

Inadequate Sars-Cov-2 Vaccine Effectiveness in Pts w/ Multiple Myeloma: A Large Nationwide Veterans Affairs Study [11/5/21; oral: 12/12/21] Nathanael Fillmore et al. Abstract 400 #ASH21 ow.ly/upUm50H8Tru #COVID19Vaccine #mmsm #COVID19nCancer #IDonc

Racial and Ethnic Differences in Clonal Hematopoiesis, Tumor Markers, & Clinical Outcomes of Patients with Multiple Myeloma [Nov 5, 2021; oral: 12/12/21] Nancy Gillis 🆖☮️ et al. Abstract 402 #ASH21 ow.ly/gJ0u50H8TM4 #mmsm #cancerdisparities SETD2 (6% Blck v 1% Wht, p = 0.037)

Genomic Profiling of Smoldering Multiple Myeloma [SMM] Classifies [6] Molecular Groups with Distinct Pathogenic Phenotypes and Clinical Outcomes [Dec 13, 2021] Shankara Anand et al. . Abstract 723 #ASH21 ow.ly/ptnr50GHnJF #mmsm #PrecisionMedicine

Whole-Exome Sequencing Identifies a Somatic Cell Mutation Signature That Predicts Relapse Risk and Survival Probability in Multiple Myeloma [Dec 5, 2020] Ehsan Malek et al. #ASH21 Abstract 1355 ow.ly/tZPE50Iwy7I #mmsm #cagenome

FISH and WGS in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma – WGS Will Affect Future Treatment Decisions [Oral: 12/12/21] Marietta Truger et al. MLL Munich Leukemia Laboratory Abst 397 #ASH21 ow.ly/Ufj850I69uh #mmsm #cagenome #PrecisionMedicine

Drug Class Refractoriness, Not Number of Prior Lines of Therapy (LOT), Properly Classify Pts w/ Relapsed / Refractory Multiple Myeloma (RRMM) Receiving Contemporary Regimens [Dec 12, 2022] Luciano J Costa et al. Abst 4530 #ASH22
ash.confex.com/ash/2022/webpr… #mmsm #ClinicalTrials #caxtx

Role of TNFRSF17 and GPRC5D Structural and Point Mutations in Resistance to Targeted Immunotherapies in Multiple Myeloma (MM) [Dec 10, 2022] Lee et al. Abst 101 #ASH22 ash.confex.com/ash/2022/webpr… #mmsm #CARTcell #PrecisionMedicine

Global Treatment Standard in Multiple Myeloma Remains Elusive: Updated Results from the INSIGHT MM Global, Prospective, Observational Study [Dec 10, 2022] Noemi et al. Jesus Berdeja, MD Abs 1859 #ASH22 ash.confex.com/ash/2022/webpr… #mmsm #globonc

North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need [Feb 9, 2023] Naveen Pemmaraju, MD et al. Andy Lane Blood Journal ashpublications.org/blood/article/… #BPDCN

Bone marrow clonal hematopoiesis is highly prevalent in blastic plasmacytoid dendritic cell neoplasm & frequently sharing a clonal origin in elderly Pts [3/12/22] Mahsa Khanlari et al. ⁦Sa A Wang, MD ⁦Leukemia Journal ow.ly/VLI450IiSs6 #BPDCN #CHIP #hemepath #hemepath MDA #leusm

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) on Social Media: #BPDCN -Increasing Exposure over Two Years Since Inception of a Disease-Specific Twitter Community [Oct 18, 2018] Naveen Pemmaraju, MD Audun Utengen Vikas Gupta Mike Thompson, MD, PhD, FASCO Andy Lane CHMR ow.ly/a41K30mj2Q0

Social Media in Academic Hematology: Focus on Rare Cancers [Jan 25, 20/17] Naveen Pemmaraju, MD Oncology Times ow.ly/1wBy308pjaO #MPNSM #BPDCN

Social Media & Internet Resources for Blastic Plasmacytoid Dendritic Cell Neoplasm #BPDCN [Aug 4, 2016] Naveen Pemmaraju, MD et al. ow.ly/hrcX302XmIn

. BPDCNinfo -- Dedicated to raising awareness of blastic plasmacytoid dendritic cell neoplasm ( #BPDCN ) -- a hematologic cancer that can be dangerously unseen. bpdcninfo.com

#BPDCN = Blastic plasmacytoid dendritic cell neoplasm. Follow the ongoing conversation at #BPDCN

ABIM Maintenance of Certification (MOC) for physicians is a redundant imposition leading to burnout and resentment.

Physicians are voicing their concerns to the DOJ which wants to hear from us. See thread for link.

National Board of Physicians and Surgeons Aaron Goodman - “Papa Heme” obroncology.com/article/oncolo…