Special thanks to her fantastic committee, incl. her committee chair Schaefer Lab (pictured), Scott Russo , Cameron McAlpine , and Lucas Cheadle for invaluable guidance. She's seeking postdoc opps. in the Boston area (incl. NH/RI)—reach out if interested! #PhDone #ProudAdvisor

Excited to share a new preprint out from the lab (biorxiv.org/content/10.110…) by 1st-author Brittany Hemmer , a newly minted PhD from the lab! A brief thread on what we found (1/n):

Happy 80th birthday to HDF's President, Nancy Wexler! Send Nancy a personal birthday message - we'll share it with her. Your words will mean so much to her! #Huntingtonsdisease #curehd HDBuzz The American Brain Coalition

Linear Scaling Causal Discovery from High-Dimensional Time Series by Dynamical Community Detection journals.aps.org/prl/abstract/1…

Stop by poster #133 to learn more about immunimetabolism on AD! #AAIC25 Alzheimer's Association

Yeah gold days.

Totally! I actually installed MS-DOS from really floppy disks (the five and a quarter inch variety).

Telescopefish, a rare deep-sea creature known for its eyes adapted for spotting bioluminescence

This was indeed my first computer!!! I remember it fondly (especially the keyboard) 🙃

#vim vs #llm superpowers, which one would you choose? 🤯 youtube.com/shorts/pp_JJiB…

Epigenetics Update - Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience bit.ly/4lel7uV #Epigenetics #Multiomics #AlzheimersDisease #SingleCell --- Discover the breakthrough at epigenometech.com

I think a good rule of thumb is to spend at least as much time thinking about your data as you did obtaining it. It's common for people to spend a lot less time thinking than doing which gives rise to all kinds of problems.

Here we go again. Another paper showing that putting arrows on UMAPs (RNA velocity) is biological gobbledygook. biorxiv.org/content/10.110… How many more such papers are needed?

"Good Description" osf.io/preprints/soca…

This was animated in 1987

Another great essay by Martin Schwartz...J Cell Science "It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and

That's how I teach probability to my students... way more satisfying than starting with gambling!

🤨

I'm often asked how human genetics can be used to validate drug targets. In our new Nature Cardiovascular Research paper, we provide an end-to-end framework for IL-6 inhibition🧵 👉build a genetic proxy 👉demonstrate potential for cardiovascular benefit 👉assess expected & unexpected safety signals

Thinking Like a Scientist: Definitions There's something weird going on in Alzheimer's genetics... In 2010: Studied 1,594 patients → found genetics explains 42% of disease In 2021: Studied 1,126,563 patients → genetics explains 3% What's changed?🧵