Our latest paper is out in Genome Biology!!! Here we present a method to identify genomewide hotspots where replication forks stall or pause. These sites are associated with increased DNA damage and overlap with breakpoints of cancer rearrangements doi.org/10.1186/s13059…

Very interesting study on the mitotic role of PolQ in driving structural genome aberrations upon replication stress biorxiv.org/content/10.110…

We have a open position for a post-doc on a very exciting project in a constructive and fun team. see details in the link below: werkenbijumcg.nl/-/vacatures/po…

Very happy our scEdU-seq manuscript is published in Nature Methods! Big shoutout to vincentvB, Alexander van Oudenaarden Marcel van Vugt, Sergio Perez Acebron and Anchel de Jaime-Soguero for their contribution to the final product! For those interested here is the link to the paper rdcu.be/dK2hL

Searching a PhD student for an exciting structural biology project on DNA mismatch repair: "Uncovering mechanistic effects of clinical MMR variants with partial activity" nki.nl/careers-study/… #NKI #Oncode

It’s happening again! Mark your calendar 10 - 13 Jun 2025 and join us for the 2nd The ageing genome: from mechanisms to disease symposium embl.org/about/info/cou… via EMBL

The Cortez lab (lab.vanderbilt.edu/cortez-lab/) is looking for new postdocs or senior scientists. If you are interested in genome stability, replication, DNA repair, or DNA damage responses please send me an email.

I am very happy that we are featuring this piece NatureStructMolBiol. For what my opinion is worth, curiousity-based research bears exceptional societal potential and advantageous fiscal multiplier-effects. This thoughtful and eloquent piece presents such a success story.

Our new paper in Nature Communications shows that Fanconi anemia proteins promote end resection to repair double-strand breaks by homologous recombination. Great work by Bert van de Kooij, Fenna van der Wal, with Marcel van Vugt , altmeyerlab and YaffeLab! nature.com/articles/s4146…

Very exciting work by the Ly lab!

Thrilled to share our latest story Nature Cell Biology on a new way to control protein localization without exogenous triggers (e.g., light/rapamycin)—take advantage of endogenous triggers in dividing cells! Free link: rdcu.be/dSlrS Regular link: nature.com/articles/s4155… 1/4

Ever wondered why cancer cell micronuclei rupture irreversibly? The answer is in my first-author paper in the Samuel Bakhoum lab and its back-to-back companion from Stefano Santaguida lab out today in Science Magazine and featured on its cover ✨(1/6) science.org/doi/10.1126/sc…

Out in nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis!  Link: nature.com/articles/s4158…

Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance WTCCB Cell Biology Gene Center Munich Biological Sciences | University of Edinburgh Universität München Pragya Srivastava Bethan Medina-Pritchard Alba Abad Paula Sotelo European Research Council (ERC) dhafer ben khalifa & MRC science.org/doi/10.1126/sc…

Thrilled to announce our latest bioinformatic study in Nature Communications! If your interests are genome maintenance mechanisms in mitosis or DNA repair check out this rich resource of new genome maintenance candidates doi.org/10.1038/s41467… #dnarepair #replication #AlphaFold #Cancer