One of my postdoctoral efforts from Bas van Steensel lab is now out on bioRxiv. We tried to tackle a longstanding question: 'What mediates transcription repression in Lamina-associated domains?'. Thanks to all the authors for their contributions.
biorxiv.org/content/10.110…

what were the favorite metabolites of the ancient egyptian pharaohs?

pyrimidines

At long last, the in4mer paper is published! In4mer is our CRISPR/Cas12a platform, developed in collaboration with John Doench, where we show that expressing 4mer arrays of Cas12a guides turns out to be a highly efficient way to knock out genes singly or in combination.

I was asked this question very often: “Tommy, what’s the p-value cutoff should I use to determine the differentially expressed genes; what log2 Fold change cutoff should I use too?” New blog post: Bioinformatics is not (just) statistics divingintogeneticsandgenomics.com/post/bioinform…

x.com/i/article/1780…

We are looking for a postdoc to join our team in Cancer Cell Biology lab at Institute of Molecular Genetics to investigate how defects in cell cycle checkpoints drive tumorigenesis. Interested candidates with expertise in cell biology, 3D cultures or protein biochemistry apply: [email protected]

Check out our game, DEGRADATOR! 🎮 Designed to popularize and educate on the ubiquitin-proteasome system and PROTACs. Perfect for kids 12+ but not only 😉 Dive into 10 fun levels to explore protein degradation. Available on Google Play and degradator-game.com 🚀

It was an absolute pleasure presenting our scEdU-seq technique during the single-cell network Netherlands conference at PrinsesMáximaCentrum. Big thanks to the organizers of the meeting!!

#dnareplication #singlecell #techdev #genomestability

I am very excited, what an honour!

Honored to receive an ERC Advanced Grant to study the interaction of the chromatin landscape with 3D genome organization in Epigenetic Cell Memory 🎆 🍾 Very excited to start exploring these basic mechanisms that maintain cell identity across our lifespan 🤩 The Groth Lab CPRatUCPH

Hes genes are dynamically expressed in many tissues. But how do dynamics differ between tissues and are they always oscillatory?

We have addressed this question in the context of the developing embryo, where somites and neural tube form side-by-side.

biorxiv.org/content/10.110…

Amazing findings on how cells respond when nucleosome assembly is suddenly stopped 🙌🙌 Francesca Mattiroli Jeroen van den Berg Alexander van Oudenaarden

Join us for this exciting Symposium featuring Replisome structure, Origin regulation, Chromatin replication, Replication stress and Replication in Cancer etiology/treatment. Stellar speaker lineup! MANY talks selected from abstracts.

Multi-layered analysis showing the importance of DNA replication-coupled histone assembly in cells. #epigenetics #singlecells kudos to the team!

Beautiful work, congrats Francesca Mattiroli and team!!

Acute multi-level response to defective de novo chromatin assembly in S-phase biorxiv.org/cgi/content/sh… #bioRxiv

Check out the latest pre-print from our lab. Amazing work from Jan Dreyer, Giulia Ricci and Jeroen van den Berg. True team work with many essential collaborators Alexander van Oudenaarden Anja Groth 🇺🇦, Sabrina Spencer, Vivek Bhardwaj and many more. Feedback welcome!