Very excited to receive the ASBMR “Most Outstanding Translational Abstract Award” for my talk on Oct 13th- 1001: on #breastcancer and osteocyte senescence. w/ Manish Adhikari Hayley Sabol Aric Anloague , others & PI Jesus Delgado-Calle #ASBMR2023. UAMS Physiology & Cell Biology UAMS Health UAMS Cancer

The senescent cells that drive #aging related diseases are notoriously hard to identify —but now Mayo researchers have done just that. They’ve developed a new technique to pinpoint these rare cells in bones, where they can lead to #osteoporosis. mayocl.in/3ZK2Gp2

#SenMayo man on #ASBMRbonethrone

Our new preprint sheds light on the distinct role of p16- and p21-associated SASP across tissues and species. biorxiv.org/content/10.110… No time? Just listen to this very cool 90 sec. summary: lnkd.in/eQmY97xP @PassosLab Madison Doolittle Robyn Kosinsky Nathan LeBrasseur

Clever bioinformatic + cell-based approaches by Xu Zhang and our Mayo Clinic colleagues Madison Doolittle, Sundeep Khosla, + others to unravel how #senescent cells (FAPs) drive features of skeletal muscle #aging: Aging Cell onlinelibrary.wiley.com/doi/10.1111/ac… #sarcopenia

Excited to share our most recent work, together with Dominik Saul and Sundeep Khosla, on deeply characterizing #senescence during fracture healing. We find the cells delaying repair are a diverse mix of p21+ cells, which can be targeted to enhance healing. biorxiv.org/content/10.110…

Finally published in #JCI P21+ senescent cells play a crucial role in fracture healing: jci.org/articles/view/… Targeting these cells potentially boosts fracture healing 🦴. Thanks to Madison Doolittle Sundeep Khosla and the Mayo Clinic #aging #fracture #bone

Effect of senolytics (D+Q) on bone metabolism in postmenopausal women – a phase 2 RCT. Findings indicate that D+Q increased bone formation but did not reduce bone resorption. The clinical response to senolytics is driven by underlying senescent cell burden nature.com/articles/s4159…

New #research by 3 AFAR Grantees in Nature Medicine suggests that drugs targeting #senescentcells may benefit healthy older women but not "one-size-fits-all." Explore here: mayocl.in/4cOBiLG Nathan LeBrasseur Madison Doolittle Mayo Clinic UConn Health

Happy reading, by ⁦Gustavo Duque⁩ Giovanni Lombardi and I. ⁦⁦UniMelb MDHS⁩ Bone and muscle crosstalk in ageing and disease | Nature Reviews Endocrinology nature.com/articles/s4157…