🆕⚡🧬⚖️ HCEs Put to the Test — BALANCE & CAMERA2 Post-hoc Analyses, CMI 2025 🚀 What they did 🔍 Built post-hoc hierarchical composite endpoints (HCEs) and DOOR-style rankings for BALANCE (7 vs 14 days) & CAMERA2 (combo vs standard therapy). 🧩 Combined multiple outcomes: •

Infections don’t follow the tidy stories we tell ourselves. They follow biology, behavior, chance, and sometimes undercooked chicken. A few common myths in ID worth exploring in more detail. (Link in next tweet 👇)

🆕🔥 🫁🧯 Steroids Save Lives — Low-Dose Corticosteroids Cut Short-Term Mortality in Severe Pneumonia & ARDS, Annals of Internal Medicine, 2025 🚀 What they did 🔎 Systematic review + meta-analysis (20 RCTs( 15 severe pneumonia), 3459 adults) across severe non-COVID pneumonia &

A young student once asked a wise Monk.... MUST READ.. 🧵

🆕⚡🦀A New Twist — Once Again, Ceftazidime Avibactam Turbocharges Ampicillin Sulbactam Against CRAB | JAC-AMR 2025 🚀 What they did 🧪 In-vitro study of 184 CRAB isolates from 9 Peruvian hospitals (2018–2023). 🧬 Confirmed via blaOXA-51 PCR, MALDI-TOF, and 16S rRNA where

💊𝗧𝗿𝗮𝘁𝗮𝗺𝗶𝗲𝗻𝘁𝗼 𝗱𝗲 𝗧𝘂𝗯𝗲𝗿𝗰𝘂𝗹𝗼𝘀𝗶𝘀 (𝗖𝗗𝗖 𝟮𝟬𝟮𝟱)‼️ ⬇️⬇️⬇️⬇️ ❌ 𝙀𝙩𝙝𝙖𝙢𝙗𝙪𝙩𝙤𝙡 𝙙𝙚𝙨𝙖𝙥𝙖𝙧𝙚𝙘𝙚 como fármaco central en esquemas sensibles. ✅ 𝙈𝙤𝙭𝙞𝙛𝙡𝙤𝙭𝙖𝙘𝙞𝙣𝙤 𝙚𝙣𝙩𝙧𝙖 𝙘𝙤𝙢𝙤 𝙛𝙖́𝙧𝙢𝙖𝙘𝙤 𝙙𝙚 𝙥𝙧𝙞𝙢𝙚𝙧𝙖 𝙡𝙞́𝙣𝙚𝙖 𝙚𝙣

Guías #PrEP👉🏻screening ITS 3-6 meses pero datos sobre esto #escasos.En @Lancetmicrobe en 🇧🇪solo test a SINTOMATICOS 1️⃣Incidencia #Ngonorrhoeae y #Ctrachomatis disminuyó🧫📉 2️⃣No aumento infecciones sintomáticas❌ 3️⃣Dismimuyó uso de antimicrobianos📉💊 🔗🆓thelancet.com/journals/lanmi…

🚨 Francia confirma 2 casos importados de MERS-CoV en viajeros que regresaban del Oriente Medio. 🔗 Noticia: bnonews.com/index.php/2025… ⸻ 🦠 ¿Qué es el MERS-CoV? • Coronavirus zoonótico identificado en 2012 en Arabia Saudí. • Hospedador primario: dromedarios 🐪. • Transmisión

🆕⚡💊 A SNAP Moment — Flucloxacillin Variability Raises a Wake-Up Call to Shift Toward Safer MSSA Options(FLUTE study) |JAC 2025 🚀 What they did 🔬 Retrospective study of 203 hospitalized patients receiving flucloxacillin. 🧪 Measured unbound flucloxacillin ≥48h after

🆕⚡🦠 Aztreonam-Avibactam — The Undisputed Hero 🏆 Tackling MBLs Like a Pro| AAC/2025 🐯 Tigecycline — “The Tiger,” still strong and reliable but not in BSI. 🐴 Cefiderocol — Once the Trojan Horse, but not the soldier we hoped for 🎯 Cefepime-Taniborbactam — Targets MBLs, yet

Revisiting tuberculosis diagnostics: progress, pitfalls, and future directions doi.org/10.1016/j.cmi.…

Imprescindible actualización sobre la sífilis (incluye la profilaxis post-exposición con doxiciclina). jamanetwork.com/journals/jama/…

LANCET 2025: Insuficiencia cardiaca con FEVI reducida doi.org/10.1016/S0140-… #MedEd #MedTwitter #MedX medicina-interna.org

Chain of tragic events: 🦨 Skunk → donor scratch → 🏥 • 1️⃣ Kidney recipient (MI) → 💀 5 wks: tremors, weakness, confusion, urinary incontinence • 🧬 CDC: Rabies RNA detected postmortem (brain) of kidney recipient. • 3️⃣ Cornea recipients → ✂️ Explant + 💉 PEP • 370

The most downloaded article in 90 days in CMI Communications #IDXposts

🆕⚡🧬🧩 The Sepsis Puzzle: Precision Immunotherapy Finds a Missing Piece | ImmunoSep RCT | JAMA, 2025 🚀 What they did • 🧪 RCT (double-blind, double-dummy, placebo-controlled) across 🌍 6 countries • 👥 276 adults with Sepsis-3 + immune dysregulation • 🔍 Stratified by

Ddx

Current Management of Serious Infections due to Vancomycin-resistant Enterococci doi.org/10.1016/j.idc.…

🆕🔥EMPHASIS RCT A multicentre, double-blind, RCT N:1724 Minocycline therapy initiated within 72 h of acute ischaemic stroke provided a significant functional outcome benefit compared with placebo at 90 days, without safety concerns #IDXposts thelancet.com/journals/lance…

Clinical Management of Staphylococcus aureus Bacteremia: A Review | Infectious Diseases (jamanetwork.com/journals/jama/…)