People have long thought that astrocytes release something that kills neurons, which could partly explain why neurons die in injury/neurodegenerative disease. In a paper that just came out, we think we found one of these long-sought toxic factors! (1/8) go.nature.com/3afi6si

Severe Covid and the #brain: infection can induce "string vessels" in patients due to death of endothelial cells (lining blood vessels), signifying microvascular damage, verified in experimental models nature.com/articles/s4159… Nature Neuroscience

Happy holidays from the Crouch and Huang labs! Loukas Diafos

Early morning from the west coast Chan Zuckerberg Biohub Network spatial transcriptomics summit talking about standardization, best practices, and what’s missing. Thanks Aparna Bhaduri and Nowakowski_Lab for your excellent moderating.

Thrilled to celebrate Kaylee Wedderburn-Pugh who was awarded an American Heart Association Diversity supplement AND had a birthday last week! Can’t wait to see those experiment results. With Loukas Diafos @edward_jvt Sneha Rao at @stem_at

When you are not sure what the code does but assume it must be important so you just leave it

I'm blessed to have been a part of this special moment with my PI and team. A bit of bubbly and pizza to celebrate the acceptance of our lab's most recent manuscript submission. Congratulations to Elizabeth Crouch, MD/PhD and everyone involved! Loukas Diafos Janeth Ochoa Birrueta Kaylee Wedderburn-Pugh

In new Cell study, Elizabeth Crouch, MD/PhD & UC San Francisco colleagues are first to show how blood vessels develop in the prenatal human brain, paving way to understand the cells’ role in health brain development & disease. ucsf.edu/news/2022/09/4…

Beyond excited to be sharing this! Such a great experience working on this paper with some amazing scientists and people

Come visit my poster this afternoon! Also featuring work from Aparna Bhaduri Andrés Martín Kaylee Wedderburn-Pugh @edward_jvt Janeth Ochoa Birrueta Loukas Diafos Jayden Ross Arnold Kriegstein Arantxa Cebrian-Silla Society for Neuroscience (SfN) #brainvascular #braindevelopment UCSF Benioff SF UCSF Broad Stem Cell UCSF Neonatal-Perinatal Medicine

Join us on Thursday, January 19 1PM EST for our next Journal Club! Loukas Diafos Loukas Diafos will discuss the paper co-authored with Dr. Elizabeth Crouch, MD/PhD “Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain” Register at bit.ly/3in2H0Z

Our work on human fetal brain haemorrhage and SARS-CoV-2 is out in Brain! We show that cortical haemorrhages in the fetal brain are associated with the presence of SARS-CoV-2, reduced blood vessel integrity and increased immune cell infiltration academic.oup.com/brain/advance-… 1/3

Congratulations to Center Investigator Elizabeth Crouch, MD/PhD receiving an ASCI's Young Physician-Scientist Award!

Congrats Kaylee Wedderburn-Pugh for successfully completing your qualifying exam Graduate Education and Postdoctoral Affairs and Loukas Diafos for completing your masters degree King's College London! 🫀🧠Very proud of you both #crouchlab Tippi MacKenzie UCSF Broad Stem Cell

Science party in PodA! Grateful for the community and expertise in my neighborhood. UCSF Broad Stem Cell @edward_jvt Loukas Diafos Kaylee Wedderburn-Pugh Jayden Ross Kyle Cromer Ernesto J. Rojas Joanna Halkias Tippi MacKenzie

Pleased to post our Nature Protocols pub profiling human vasculature using transcriptomics and organoids 🧬🧠🧫. rdcu.be/dtHaO Building off previous work in 🐭brain, we describe human specific procedures for #flowcytometry #neurovascular #organoids & #transcriptomics

Delighted to present our latest preprint on Glioblastoma Neurovascular Progenitors (NVP), which explores how these cells orchestrate tumor cell type diversity. Led by the exceptional Elisa Fazzari! Check it out: biorxiv.org/content/10.110…

#Crouchlab and friends and family at the UCSF Center for Maternal-Fetal Precision Medicine 10 year anniversary celebration 🍾 🎉thrilled to be a part of this #visionary group now w/#clinicaltrials for #inutero therapies. Let’s go for it, for children’s future health 👶🏻👧🏾🧒🏼UCSF Pediatrics Neo Kids On The Block UCSF Broad Stem Cell