Probably the best book written on time management in English in the modern era (because it turns the concept on its head; showing how much we've got 'time' wrong.) Great read by Oliver Burkeman 4000 weeks is all we have on this earth, if we live around 80 years!

Happy #DNADay! 🧬 This is one of my favourite pieces I made for Scientific American about genome sizes across select species. Was really fun to make this! #science #DNA #genome #infographic #sciart #genomics #genetics #genes

>手ぶらでサイエンス、時々BBQがコンセプト なんかすごいな 茨城つくば市で新興支援に厚み、BBQ付きラボや後方業務：日本経済新聞 nikkei.com/article/DGXZQO…

Super nice when people asked me if they can use my repository for teaching. I always say yes. Friends don’t let friends make bad graphs repository: github.com/cxli233/Friend…

Long-Read Nanopore Sequencing Boosts Structural Variant Analysis in 1000 Genomes Project Dataset genomeweb.com/sequencing/lon…

Zotero is the best citation management tool for academic writing. And it's new version — Zotero 7 — is now available for use. Here's how to automate your citations and references with Zotero 7. You can learn this workflow in 15 min:

学習院大がBVのMitoGenic を設立　ミトコンドリアを増やし活性化させるマイトルビン（漢方由来のアルカロイド）を発見　老化に関連したさまざまな疾患の治療や創薬等ミトコンドリアの研究成果の社会実装を目指し超高齢社会における健康寿命やQOLの向上に貢献u-presscenter.jp/article/post-5…

Thanks Holden for being a role model for autistic people worldwide. Your willingness to share that you are autistic and Editor in Chief of Science, one of the premiere journals in our field, will inspire and empower many people & celebrates neurodiversity science.org/doi/10.1126/sc…

“Writing is nature’s way of telling us how lousy our thinking is.” — Leslie Lamport

Today, RGC has published an important paper in nature today, describing an analysis of close to a million human exomes (n=983,578) as a single variant call set (!). This is the largest and most diverse rare variant database created so far. This impressive feat is accomplished by

みなさん!!!!!みなさん!!!!!!!!みなさん!!!!!!!!😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭

A variant in RNF213, more commonly observed in Asian individuals, is 2.3-fold enriched among those with vasospastic angina vs controls in the heterozygous status & 18-fold enriched in the homozygous status jamanetwork.com/journals/jamac… JAMA Cardiology

理研らは冠攣縮性狭心症に特徴的な遺伝的変異を最大規模のGWAS で検出　特異的で稀な疾患感受性領域は第 17 染色体のRNF213 遺伝子のミスセンス変異で冠動脈疾患全体では関連性が報告　この変異が冠攣縮性狭心症に特異的　冠動脈疾患と冠攣縮性狭心症は異なる病態と示唆nikkei.com/article/DGXZRS…

｢BMI×ゲノムで2型糖尿病の遺伝的リスク予測精度を向上｣ ･ 阪大学、東京大学、東北大学 ･ 肥満ではない集団で、2型糖尿病の遺伝的なリスク予測がしやすいことを発見 ･ 日本人に多い非肥満2型糖尿病の大規模ゲノム解析で、インスリン分泌影響の遺伝因子があることを実証 technologyreview.jp/n/2024/06/13/3…

#これでフォロワーさん増えました 「憧憬」 2022年11月 長崎市 写真トレス作品です

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Another example that combining rare variant information in a score (RVS) and adding this to polygenic risk scores (PRS) can improve prediction 👉1,752 coronary artery disease cases and 3,019 controls 👉Japanese population medrxiv.org/content/10.110…

Metabolic fluxes🔄(metabolite turnover rates) can be imputed from transcriptomic data! 👉Genetically proxied fluxes influence cardiovascular risk nature.com/articles/s4146… 👉New work shows they also influence how risk alleles affect disease susceptibility medrxiv.org/content/10.110…

Spaln3 by Osamu Gotoh: academic.oup.com/bioinformatics…

In Joseph Rich et al. biorxiv.org/content/10.110…, we assessed the Seurat and Scanpy single-cell packages, finding that they produce very different results on standard analyses. A new paper in eLife - the journal looking at clustering finds the same elifesciences.org/reviewed-prepr…