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How does exercise and fitness promote healthy brain aging? An outstanding, comprehensive review The Lancet reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more thelancet.com/journals/lance… Atefe R. Tari Ulrik Wisloff CERG NTNU

I am excited to present our new study out in Nature Medicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the Tony Wyss-Coray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

I am biased as a geneticist but think the biggest breakthrough in chronic diseases in the last few decades was the UK Biobank - now followed by other national biobanks, x.com/CarlosEAlvare1…. 5/

IBS is Not Your Fault. Early Life Adversity, Stress, Diet may be to blame #IBSAwarenessMonth #IBS #GITwitter #MedTwitter nature.com/articles/nrgas…

Now published: TRAILBLAZER-ALZ-6 study—an ongoing Phase 3 trial in early symptomatic Alzheimer’s disease. See 24- and 52-week results of different dosing regimens of an amyloid-targeting therapy on ARIA and amyloid lowering. #Alzheimers View more: e.lilly/41Fps2z

Some people with high amyloid and tangle load are more resilient to cognitive decline than others. A new synaptic protein measure could help explain why. Stanford University Hamilton Oh Tony Wyss-Coray @Brainresilience ow.ly/W2Xh50VuZbC

I am starting to think “fit” may be the biggest factor. science.org/doi/10.1126/sc…

Dr. Young says he is happy that I am excited about studying circadian rhythms. Geeking out a bit. Am I allowed?

The gastrointestinal tract contains over 100 trillion bacteria—approximately 10x the number of human cells. These microbes influence brain function via immune, neuroendocrine, and neurotransmitter pathways. Let’s explore the mechanistic pathways linking gut dysbiosis to

NEW STUDY finds COVID-19 accelerates epigenetic aging, based on multiple clocks, more so in women. Another reason to reverse it 🙏 tinyurl.com/3rdtwdf6

Join us!

Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter | Nature Communications nature.com/articles/s4146…

🚨 Covid has deleterious effects on the brain, causing both new & accelerated cognitive decline. Via WSJ:

instagram.com/p/DIfAQsFNKgd/…

From my original undergrad notebook- name this tune:

🧠 Janelia researchers have mapped out the step-by-step process of cognitive map formation in the brain’s hippocampus during learning and identified the type of mathematical model that best reproduces this learning process ➡️ janelia.org/news/mapmaking…

Let’s do this!

New in The Journal of Prevention of Alzheimer’s Disease: Appropriate Use Recommendations (AUR) for an amyloid-targeting therapy (ATT). #Alzheimers View now: e.lilly/3RRrN62

Disruption in cortisol’s rhythmic delivery is increasingly linked to psychiatric disorders, including depression and PTSD. Cortisol is secreted in ultradian rhythms ~1-hour pulses throughout the day that regulate stress response, emotional regulation, and sleep. It’s not the

NEW STUDY: A chain of sugar molecules from seaweed called “fucoidan-FV” reduces cellular senescence, promotes DNA repair, and improves health in mice 🐁 researchsquare.com/article/rs-661…