soria (@jsoriamd) 's Twitter Profile
soria

@jsoriamd

SVP Oncology Global Development @Amgen, Physician-Scientist, Medical Oncologist, immune and molecular target-believer, Tweets my own

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linkhttps://fr.linkedin.com/in/jean-charles-soria-md-phd calendar_today15-03-2012 16:06:58

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soria
@jsoriamd

7 months ago

🧬 MSI-H = hallmark of mismatch repair (MMR) deficiency. 🧵 Prevalence: ~30% endometrial, ~10% CRC, ~8% gastric. But not all MSI-H/dMMR tumors are alike: 1️⃣ MSH2/MSH6 loss → ↑ TMB, better ICI response 2️⃣ PTEN/AKT1 mutations → ICI resistance Checkpoint blockade is now 1L in CRC

🧬 MSI-H = hallmark of mismatch repair (MMR) deficiency. 🧵 Prevalence: ~30% endometrial, ~10% CRC, ~8% gastric. But not all MSI-H/dMMR tumors are alike: 1️⃣ MSH2/MSH6 loss → ↑ TMB, better ICI response 2️⃣ PTEN/AKT1 mutations → ICI resistance Checkpoint blockade is now 1L in CRC