#ncRNA molecules are stranger than you think. We propose that OLE RNA is bacteria's functional mimic of #mTOR. The Das lab at Stanford proposes OLE RNA penetrates cell membranes! They also find that RNAs we called ROOL and GOLLD form 8-membered nanocages. biorxiv.org/content/10.110…

🚨 New Research Alert! 🚨 How do bacterial contractile injection systems (CIS) like those in Streptomyces coelicolor function without extracellular targets? 🤔 🧬 We uncovered the role of CisA, a membrane adaptor protein critical for CIS-mediated cell death.

🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕

Read the paper: science.org/doi/10.1126/sc… Our blog post: evolutionaryscale.ai/blog/esm3-rele…

🆕 #preprint by Karagoz lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) biorxiv.org/content/10.110… As always let us know what you think!

Ever wondered how Pol II speed is controlled during productive elongation? Our study reveals that the helicase RECQL5 triggers transcription braking, while the transcription-coupled DNA repair complex restores the elongation rate. #cryoEM #transcription biorxiv.org/content/10.110…

People who are more extrinsically motivated – those interested in fame, power, and money – are more likely to do unethical things to advance their careers, new research shows. news.stanford.edu/stories/2025/0…

Our paper “Blocking IF3N delays bacterial translation initiation” is out on #biorxiv Awesome work from Ana Sanchez-Castro and Katherin Peñaranda in collaboration with friends from WilsonLab and Andrey Konevega labs! biorxiv.org/content/10.110…

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in Science Magazine 🎉 You can find the full story here science.org/doi/10.1126/sc… Verena Resch did a wonderful job on the cover and animation👩‍🎨

1/2 Here we unexpectedly find that protein S20/L26—identified at the dawn of ribosome research but then deemed a ribosome isolation artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation: nature.com/articles/s4146…

Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. biorxiv.org/content/10.110… #cryoEM #transcription #splicing

Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with Inada Lab and Zaher lab. Data collected at Dubochet Center for Imaging (DCI). PNAS pnas.org/doi/10.1073/pn…

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…academic.oup.com/nar/article/53…

Check out our new paper on the entire E. coli type 1 pilus structure. Many thanks to all coauthors! nature.com/articles/s4146…

Sharing some of my PhD work that just came out today. TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5) nature.com/articles/s4159…

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin Mankin_Vazquez_Lab identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… researchsquare.com/article/rs-692…