Hello everyone, Happy to share my latest work published in Molecular Cell. The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis lnkd.in/gnqgdjM4

The article: Powerhouse of the cell, written by Phillip Siekevitz in 1957 for Scientific American appears to be the origin of this popular phrase. -You can get a .pdf copy here: dropbox.com/sh/9l71qau7cql… #mitochondria #biochemistry

Deep metabolomics in 87 human hearts, DCM vs controls: our new manuscript in Nature Cardiovascular Research today, led by Emily Flam, Cholsoon Jang. lots of details! fatty acid import down; gates open at PDH complex; profound lipid derangements; &more. check it out: nature.com/articles/s4416…

📢#Mitochondria and #Cancer drug resistance📢 How much energy does it cost to run drug efflux pumps? This and more are what we set out to answer in our latest work, just published in BBA – Bioenergetics. sciencedirect.com/science/articl… 🧵below 1/

Today, we and ⁦⁦Rebecca Ganetzky⁩ report ⁦NEJM⁩ a remarkable case of twin boys with euthyroid hyper-metabolism (low body weight despite high caloric intake), due to a de novo mutation in mito CV that uncouples respiration from ATP synthesis. nejm.org/doi/full/10.10…

1/n. Final version now online Molecular Metabolism! Especially for labs newer to metabolomics, we hope this clarifies the need to freeze tissues immediately after loss of perfusion to preserve the in vivo metabolism. sciencedirect.com/science/articl…

Delighted to share a new collaboration between Daniel Fazakerley lab and TVPLab. We show that many common metabolic cell culture models, despite living in 18% oxygen, are hypoxic - with major consequences for phenotypes! Inst Metabolic Science-Metabolic Research Labs British Heart Foundation Medical Research Council 🧵 biorxiv.org/content/10.110…

Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation nature.com/articles/s4146…

Everyone studying fat knows that brown fat is “multilocular” (contains many small lipid droplets). But how and why do brown adipocytes organize their lipid stores in this way? Excited to finally share my PhD work on CLSTN3β, now published online nature! nature.com/articles/s4158…

Our latest Review on Metabolites as signaling molecules is now available Nature Reviews Molecular Cell Biology. Co-Written by the incredible Steve Baker (Steve Baker) University of Utah Pathology ARUP Laboratories go.nature.com/3GGLRCk open access:rdcu.be/c3h4g HHMI U of Utah Dept of Biochemistry

Happy to share my postdoc article nature from the Metallo lab Salk Institute on the role of serine in the development of diabetes and its complications. It was an enjoyable and truly collaborative project Knight Lab Satchin Panda @AChaix_UofUtah nature.com/articles/s4158…

Excited to share an updated version of my postdoc work, where we found that solid tumors make ATP slower than most healthy tissues nature.com/articles/s4158…

Our work on the discovery of a biochemical mechanism through which lactate regulates protein function, cell cycle, and proliferation, is out today in @nature. Congrats to lead authors Weihai, Yun, Luiz Bozi & Patrick! A 🧵 @HarvardCellBio Dana-Farber nature.com/articles/s4158…

Our review on metabolite sensing in mitochondria by @YuyangLiu9

Is lactate really a ’phoenix risen’ that drives numerous beneficial effects of exercise? Our new study in Nature Metabolism reveals major methodological flaws that affect studies of sodium lactate and potentially also other metabolite salts. Thread 👇 1/16 nature.com/articles/s4225…

In the latest issue! What is cancer metabolism? dlvr.it/SmRjrZ

1. Excited to share our new story published today in eLife - the journal, a 🧵(1/n) elifesciences.org/articles/78335

Metabolites don't just flux, they signal too. See our review in Nature Cardiovascular Research on how they do so in the heart -- a burgeoning field with huge potential for discovery: rdcu.be/dcZPv

Time for summer fun 🌞⛱️: let's talk about the Crabtree effect 🦀🦀, an ultimate #metabolismclassic, describing the ability of glucose to represses mitochondrial respiration ncbi.nlm.nih.gov/pmc/articles/P… 1/n

Our preprint show that knock-in mice with drastically reduced levels respirasomes have normal OXPHOS function and no obvious phenotypes! Very unexpected results indeed! Presented the story at EuroMit. Thanks all coauthors for a very nice collaboration! biorxiv.org/content/10.110…