Northern Lights over Iowa this evening. A geomagnetic storm to defy the notion of Fly-Over States.

Energizing two days with the brilliant students and faculty Stanford Chemistry and Sarafan ChEM-H trading insights into therapeutic modularity, molecular glues, chembio and careers. Better together. Thx for the shout-out Carolyn Bertozzi, and most of all to rockstar hosts Hlib and

Delighted to see this work on the first inhibitor/degrader of the Werner Helicase (WRN), finally published. A genetically defined synthetic lethality, to be tested in the human model system of disease. Congratulations to all from NIBR who led this program. nature.com/articles/s4158…

CRBN FTW

Is there an extended cut to this interview? I could listen to Stuart Schreiber all day long.

Direct inhibition of transcription factors remains a high hanging fruit in therapeutic science, but avails a chance to rewire pathologic cell states. Just delighted to see this master class in drug hunting finally disclosed and published. So hopeful that IAG will help patients

“Consensus changing” chemical biology at its finest, a new approach to modulating gene control. Neormorphic covalent ligands redirect the intently studied FOXA1 transcription factor, and instruct on pioneering functionality. A first TF-DNA glue? Way to go Michael Erb and Ben

ICYMI and especially ICYMB.

Congratulations, Jean-Charles on your appointment to the AACR Board of Directors. They will so benefit from both your incisive insights into cancer medicine and total commitment to the cancer patient. #MyCompany

Real progress in colorectal cancer detection by genetic detection methods in both blood and stool, but sensitivity still lags IMO. If average risk 45 years or older, discuss colonoscopy with your PCP!

Killer use of dTAG to study the fast biology of PP2A. Numerous new substrates annotated.

I love this paper from David R. Liu and Eric Fischer, and further optimized ZnF tags are warmly welcome. Question for you two: in the abstract you speak to “problems with current degron tags”. Are there problems with dTAG? Seems fully orthogonal, small, insertable, works in vivo,

Tomorrow’s in-flight meal just became that much meatier. Congratulations Vijay Sankaran, cannot wait to digest this entree.

Very cool proteomic study of defined dinucleosomes and their capacity to recruit readers and complexes. Spoiler alert: all the cool BRD4 action is in Supplemental Figure 1.

Maybe the most lovely reflection on a life well lived, amidst a cancer diagnosis, that I’ve ever read. By Simon Boas. jerseyeveningpost.com/news/2024/02/1…