Just received amazingly exciting analysis of the first 20 subjects without cancer but with Lynch Syndrome ( now fully enrolled with 138 randomized to either Anktiva plus our Adeno CANCER VACCINE versus placebo). This first set of biological immune data from NCI ( Dr Jeff Schlom)

Global expansion-first approval in Asia!! Anktiva now approved in Macau, China today. Paradigm change of treating the immune system unstoppable.

I developed Abraxane and fought for years after it was acquired that the dose should be lowered. It was hard to convince the value of low dose metronomic Abraxane and finally it was lowered for pancreatic cancer and given weekly. It was ( and still is) difficult to have busy

This is how we build the 'World Bank of NK Cells' and make Immunotherapy 2.0 accessible to all of humanity. Our M-ceNK Phase 2 clinical trials ongoing with process development from over 60 healthy volunteers and patients with cancer completed to date. The future of growing

Someone put this diagram together and it deserves to be read slowly. Three of the most disturbing psychological experiments in modern history placed in a Venn diagram with COVID policy sitting precisely at their intersection. They were not wrong. Most people know the Milgram

Another milestone in our BCG Naive randomized trial (QUILT-2.005) reached in which 50% of enrolled patients reached an evaluable time point for efficacy, triggering an Independent Data Monitoring Committee (IDMC) review to evaluate statistical power of the adequacy of the sample

Excited to be invited by a health minister in Europe to visit to establish immunotherapy2.0 ….global expansion of the power of NK and T cells. The need to address the rising number of cancer in younger patients is being realized around the world.

Did you know that Shingles incidence doubled after Chicken Pox vaccine was introduced in 1995 (**though makers insist there's no relationship)? Wouldn't it be something if Chicken Pox vaccine increases risk for Shingles in others thru shedding of the live vaccine virus or other

The more we learn about the power of IL-15 and the literature that exists decades ago (since 2010!) and never exploited is so exciting. Sepsis is responsible for over 200,000 deaths annually in the United States. We are planning a trial in community acquired pneumonia and

The one poem a young man should read above all others is: "If' From Rudyard Kipling "If you can keep your head when all about you Are losing theirs and blaming it on you, If you can trust yourself when all men doubt you, But make allowance for their doubting too; If you can

T cell Exhaustion. Immunosuppressive state. The more I learn about sepsis and why patients die in the ICU the more I’m amazed by how this state of immune collapse parallels cancer. Will be posting some seminal papers that have known about “ sepsis induced lymphopenia” for

One of our requests from oncologists treating patients with multiple myeloma is to explore how we could prevent sepsis and infections from happening. We are exploring this.

As I am converging on the role of IL-15 in cancer and infectious disease, the more I explore the literature, the more I find that the hypothesis of the "Parallels between Cancer and Infectious Disease" is correct. Early on, I believed that COVID was one of the most

The amazing dedicated team at CSSIFM treating our cancer patients with NK cells in clinical trials. So many requests from patients who have failed all standards of care and they are working so hard to file for FDA authorization as many single patient INDs as we can. Happy Easter

Imagine that the knowledge of immune dysfunction existed since 2007 of the underlying cause of death in patients with sepsis. Ironically the same year of the NCI workshop demonstrating the importance of cytokines to modulate immune dysfunction. "A new skin for the old ceremony"

Just received concerning data coming soon from UCLA and Mount Sinai clinicians about lymphopenia, covid and breast cancer metastases. Sadly our concerns of the increasing incidence of metastatic disease and recurrences of patients in remission following Covid and worse with

My daughter Annika is proudly autistic and 12 years old. She drew this butterfly from a photo she took herself — every vein, every scale, rendered by hand on a tablet. She signs everything she makes. Dates it. Like she already knows it matters. She's turning 13 tomorrow.

Great meetings today. Transforming cancer globally at scale. Cleveland Clinic