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Out today in Nature Genetics, our work utilizing single-cell multi-omics to define specific immune cell subsets that experience purifying selection against pathogenic mitochondrial DNA. nature.com/articles/s4158… Check out a thread about this work below: 1/22

Our commentary from the Jennifer Trowbridge and Ross Levine Lab on the latest clonal hematopoiesis (CH) associated condition 🧠 and it's implications for the study of CH and other aging associated diseases👇 Congrats to Siddhartha Jaiswal and colleagues!

Had a great time chatting with Rob Hasserjian about our recent work identifying aberrant TCL1A expression as a dominant reason for clonal expansion in CHIP. Listen/read about it in The Hematologist! ASH @J__Stock Jk Gopakumar Alex Bick ashpublications.org/thehematologis…

Shaneice Mitchell (Shaneice Mitchell) from the Siddhartha Jaiswal lab Stanford University is up now to present about utilizing tractable human macrophage models to investigate pathogenic features of clonal hematopoiesis.

Age-related mutations that raise the risk for blood disease also protect against brain disease! Learn how Siddhartha Jaiswal and team made this surprising discovery that challenges traditional thinking in this new study funded in part by our Initiative: neuroscience.stanford.edu/news/blood-cel…

Our latest work, led by Philipp Rauch and Jk Gopakumar in collaboration with Ben Ebert, Peter Libby, and others, on mouse models of atherosclerosis with loss of Tet2 or Dnmt3a! Really fortunate to be able to work with such a talented group. rdcu.be/dlcy1

RESEARCH|Philipp Rauch Jk Gopakumar et al. show loss-of-function mutations in either #Dnmt3a or Tet2 lead to accelerated #atherosclerosis and concordant #macrophage phenotypes Siddhartha Jaiswal Dana-Farber Stanford Medicine| nature.com/articles/s4416… 👉rdcu.be/dlYw9

Thrilled to officially launch OurHealth! Help us identify the reasons why South Asian Americans are at increased risk for heart disease, stroke, diabetes, & others. A new virtual & community-based nationwide initiative to build the infrastructure. ourhealthstudy.org

Our preprint “Determinants of mosaic chromosomal alteration fitness” is out! Alex Bick, Tara Mack, and I studied clonal expansion rate of mosaic chromosomal alterations (mCAs) in the NIH NHLBI TOPMed cohort. medrxiv.org/content/10.110… 1/7

Excited to share our review article in Blood Journal on the Causes and Consequences of Clonal Hematopoeisis This was fun to write. Hope it summarizes the state of the field to date. As always, shout out to the 🐐, Ben Ebert! ashpublications.org/blood/article/…

Conceptually flawed paper from deCODE on #CH in Nature Genetics today TLDR: Different clones have distinct disease profiles so lumping distinct forms of CH together is uninformative. #CHIP is associated with CVD in both smokers and non-smokers in full UKB 🧵nature.com/articles/s4158…

Out today in nature, we describe HHV-6 reactivation in T cells, including therapeutic CAR T cells. I’m so grateful to have worked with an all-star team during my time in the Ansu Satpathy lab that led to these findings. nature.com/articles/s4158… 1/n

Very interesting work by Rocio Vicario, Frederic Geissman and colleagues. A microglia clonal inflammatory disorder in Alzheimer's Disease biorxiv.org/content/10.110…

Out in Nature Aging today, Tara Mack & Michael Raddatz identify epigenetic and proteomic signatures associated with #CHIP clonal expansion nature.com/articles/s4358…

On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…

There has been confusion over mitochondrial mutation detection, consensus variant calling, and lineage tracing in single cells. Here, we detail how ReDeeM addresses these challenges, improving detection of mtDNA mutations by 10-fold and lineage tracing. Led by Chen Weng and

Thank you Chen Weng, @jswlab, Vijay Sankaran for the feedback on our work. LeifLudwig and I agree that the “-2” filtering method that mitigates edge bias is a critical development for ReDeeM. Nevertheless, we stand by our original preprint, noting the following: 1/n