Join our lab in Boston! You‘ll have the chance to experience great science, collaborations and Iñigo as the best PI.👨🏼‍🔬 #thyroidcancer #research #sciencejobs #boston

An extremely interesting case report about thyroid cancer with platinum signature occurring 8 years after previous platinum-based chemotherapy of ovarian cancer☝🏻Nice job Theodora and the other authors ascopubs.org/doi/figure/10.…

I'm thrilled to share our new study reporting why DNA replication timing is important for the formation of oncogenic translocations, now published in Science Magazine. In the Pavri lab, we explored oncogenic translocations in #lymphoma & #leukaemia 🧵👇 1/ doi.org/10.1126/scienc…

Single-cell ATAC-seq finds active regulatory elements across cell types, but its resolution can be limited. What if we could identify when and where proteins bind to chromatin? Introducing PRINT, a new single-cell footprinting tool from Jason Buenrostro lab biorxiv.org/content/10.110…

Cracking the "black box” using human brain organoids, truly inspiring discoveries ahead of us! 🧫🧠🧬#brainorganoids #organoids #stemcells #future #development

Registration is now open for the Berlin Summer Meeting 2023 - The MDC Celebrates 15 Years of BIMSB, 6-7 Sept, 2023: bit.ly/bimsb2023 We are looking forward to a fantastic line-up showcasing exciting new developments in #systemsbiology Max Delbrück Center

Out today in Nature Genetics, our work utilizing single-cell multi-omics to define specific immune cell subsets that experience purifying selection against pathogenic mitochondrial DNA. nature.com/articles/s4158… Check out a thread about this work below: 1/22

There is an open position available in the Landa lab! Collaborate with clinicians/researchers in the Boston/Harvard environment! Help advancing the knowledge on advanced thyroid cancers and join a leading lab in the field. #thyroid #brighamandwomens #harvardmed #boston

We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.0…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/

Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in Nature Cancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy. Broad Institute Wellcome Sanger Institute Gad Getz Laboratory Thread below 🧵 nature.com/articles/s4301…

Finally out! 👨🏼‍🔬 We describe non-telomeric effects of Tert upregulation in thyroid cancers in mice with the very first model containing a Tert promoter mutation. What a journey for this story and Iñigo. 🍻

First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns go.nature.com/47ekkUM

Rocket science is hard. Designing systems capable of launching materials—including humans—into orbit and then smoothly landing back on terrestrial ground is one of the greatest feats of engineering we’ve achieved. But surviving in space will be even harder. In his brilliant

Finally out! We found that mRNAs are not uniformly distributed across the cytoplasm. mRNA architecture is the strongest determinant for localization. Subcytoplasmic location of translation controls protein output. cell.com/molecular-cell…

Published today! 📰 Nature Medicine One of the first #cancer vaccines💉that target #KRAS. Not just G12C. 👇🏾The 2-peptide was G12D & R. The 7-Peptide/Elicio targets D R V S A C G13 ➕ NRAS Implications for so many patients! Open now. Cheers! OncoAlert nature.com/articles/s4159…

Promoter, Enhancer, Super-Enhancer- and here comes the Coordinator! Exciting read! Out in Cell cell.com/cell/fulltext/…

Landmark paper alert! Women develop more autoimmune disease -> The proteins associated with the long non-coding RNA Xist (silence the second X chromosome in women) comprise numerous autoantigenic components as important driver of sex-biased autoimmunity cell.com/cell/fulltext/…

What a great manuscript from Jakob Trendel kusterlab (Inactive) ! After XRNAX (loved it!) XDNAX helps enriching for DNA-associated proteins! Top quality paper

Join us for the 2nd ETA-ATA Trainee Joint Online Meeting 🗓️Tuesday, May 21st 8am PT🏄‍♀️ 11am EST🦃 5pm CET🇪🇺 Connect with your peers in thyroidology! F. Thurston Drake American Thyroid Association ETA - European Thyroid Association Latin American Thyroid Society BTF Thyroid Free event, register here: rb.gy/q9sgzo

Out now in Cell Reports Medicine ! 🧠🔬