Genome assembly in the telomere-to-telomere era go.nature.com/4aLqIED #Review by Heng Li Heng Li & Richard Durbin Richard Durbin Dana-Farber DBMI at Harvard Med Cambridge University

Takeaways: 1) Elections are fair; 2) EVMs are not rigged; 3) Threatening civil war is stupid - it’s an election not a war; 4) exit polls are great fun but the real thing is the actual result; 5) we are back to coalitions and we can forget about any serious reforms - economic or

Our study of the gene-vegetarianism interaction effects on 30 blood biomarkers is formally published on #PLOSGenetics dx.plos.org/10.1371/journa…

Pangene now published in Bioinformatics: doi.org/10.1093/bioinf…. In addition to showcasing applications (see the 17q21.31 inversion below), we also reviewed the theoretical formulation of bidirected graphs and discussed the definition and the finding of "bubbles" in such graphs.

I'm sharing a public version of my talk slides CGSI-The Computational Genomics Summer Institute two weeks ago - an update from my #LLMs #compbio Primer talk last year - w/ a focus on genomics FMs (DNA, scRNA). As we're exploring related topics, we remain very interested but also skeptical. 1/3 cs.cmu.edu/~jianma/talks/…

Excited to share our study on fish oil supplements modifying genetic effects on lipids, now published in American Journal of Clinical Nutrition: doi.org/10.1016/j.ajcn…. Thanks to all co-authors!

Very excited to share our primer on LLM for biology Nature Methods! We discuss how to use: ⚡️human & protein LMs (eg #ESM) ⚡️#singlecell & #multimodel LMs ⚡️when to fine-tune, transfer learn etc. Paper nature.com/articles/s4159… Colab tutorial colab.research.google.com/drive/1zIIRGeq… Written for a

A benchmark of single-cell ATAC-seq analysis packages. genomebiology.biomedcentral.com/articles/10.11…

Spatial omics have lit up life science and this new review Cell is the best I've seen cell.com/cell/fulltext/… open-access

This

We will be at #ASHG24 next week. Multiple students from the lab will be presenting their research. Look forward to it!

Zero-shot evaluation reveals limitations of single-cell foundation models genomebiology.biomedcentral.com/articles/10.11…

It is a major PhD project of Yitang Sun. I am very excited to see this work out. I learned so much about the genetics of circulating fatty acids. This is a solid foundation for more research to come regarding gene-diet interactions for omega-3 and omega-6 fatty acids.

Congrats to Huifang Xu and Yitang Sun for their tremendous efforts on this project to characterize the shared genetic basis between circulating fatty acids and brain disorders!

Have to stay at home this year for a newborn baby. But the Ye lab is well-represented #ASHG25. Check out the posters from our 7 grad students!

Happy Diwali 🪔!

So many people keep asking me about Continue. What is it? What are you up to? Here you go... Continue started as a research effort two years ago, with the belief that if the human body is a system, it should also have its leverage points. The simple levers that, when adjusted,

A spectacular win by the Indian team in the ICC Women’s Cricket World Cup 2025 Finals. Their performance in the final was marked by great skill and confidence. The team showed exceptional teamwork and tenacity throughout the tournament. Congratulations to our players. This

The $100 whole human genome sequence finally reached! Element Biosciences sandiegouniontribune.com/2026/02/19/scr…

Champions ⭐️⭐️⭐️ Phenomenal win for Team India in Ahmedabad. Absolutely no match for the explosive cricket played by us throughout the tournament. Brilliant character shown by the boys to keep fighting in tough situations and become world champions once again. Congratulations to