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Newly Identified Genes Linked to Coronary Artery Calcification advances.massgeneral.org/cardiovascular… via MassGeneral News. Excited to share a press summary of our work on the largest GWAS to date for coronary artery calcification identifying 8 novel loci with functional validation for 4 genes.

Congratulations to graduating fellows Janet Ma and Parth Patel for magnificent MGH Cardiology Grand Rounds presentations. Privileged to work with you these past 3-4 years. ⁦Doreen DeFaria Yeh, MD⁩ ⁦MGH Cardiology Fellows⁩ ⁦Patrick Ellinor⁩ ⁦

Spectacular MGH Cardiology Grand Rounds presentations by Drs. Megan Welch, Olivia Hulme, and Avanthi Raghavan spanning TTE appropriate use criteria, TAVR outcomes, and biologic mechanisms of aortopathy. ⁦MGH Cardiovascular Research Center⁩ ⁦⁦⁦Doreen DeFaria Yeh, MD⁩ ⁦Patrick Ellinor⁩

Inspiring life story at the intersection of science, medicine, tech, and industry. Thanks to ⁦Sek Kathiresan MD⁩ for sharing his journey with the MGH CV Fellows. ⁦Doreen DeFaria Yeh, MD⁩ ⁦MGH Cardiology Fellows⁩ ⁦MGH Cardiovascular Research Center⁩

📢 Today is MSMDS Awareness Day! 📢 Let's spread the voice about the ultra-rare, life-threatening disease, Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS). Learn and support gene therapy research: bit.ly/donation_gene_… #MSMDSAwarenessDay #RareDiseaseAwareness #ACTA2

Excited to collaborate with Rajeev Malhotra, Cathy Shanahan, Yabing Chen, Melinda Duer, Maryam Kavousi, Rafael Kramann, MD PhD and others on this effort!

Honored that Foundation Leducq has funded our Network, COMET: Calcification-Omics, Molecular Elucidation & Therapeutics. What a wonderful team of scientists to work alongside including Cathy Shanahan, Clint Miller Rafael Kramann, MD PhD Yabing Chen, Melinda Duer, Maryam Kavousi

Big statement alert: This is a LANDMARK in the history of clinical gene editing. This means we can dose to effect. This means we can sequentially edit targets. This means we can reverse certain edits. Cue "A whole new wooorld..."

Excited to highlight our HFpEF project, 5 years in the making! Rajeev Malhotra Greg Lewis @MattNayor Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF. jacc.org/doi/10.1016/j.… JACC Journals

Shout out to Dr. #MarcoGuazzi for his insightful editorial in regards to our manuscript on exercise physiology, oxygen pulse (#O2Pulse) and HFpEF! jacc.org/doi/10.1016/j.… Rajeev Malhotra JACC Journals UW Cardiology MGH Cardiovascular Research Center

Inspiring talk by Dr. Paul Yu ⁦on the preclinical studies performed by his lab leading to the approval of sotatercept for PAH at MGB Cardiology Grand Rounds today. ⁦Paul Yu MD PhD⁩ ⁦MGH Cardiovascular Research Center⁩ ⁦⁩ ⁦Patrick Ellinor⁩ ⁦@MGH_RI⁩ ⁦MGH Cardiology Fellows⁩

Pleasure to share my research work during the annual CVRC retreat 2024 at the Broad Institute of MIT and Harvard. Amazing speakers, inspiring talks, and cool science! Cherry on top: our lab member Adam Johnson received the Best Poster Award! 🏆 Paul Yu MD PhD Rajeev Malhotra MGH Cardiovascular Research Center @

Proud of my lab for all the wonderful science they presented at the MGH CVRC Retreat. Special congratulations to ⁦Adam L. Johnson⁩ for winning the Best Poster Award. ⁦MGH Cardiovascular Research Center⁩ ⁦@MGH_RI⁩

Congrats to our semifinalists for the #CVRC2024 retreat oral abstract prize, Greg Gipson Adam L. Johnson @KyleMentkowskil and Rashmi Richa—Kyle with top honors! A bright future for these talented young scientists. Mentors: Matthias Nahrendorf @MarkELindsay Rajeev Malhotra Paul Yu MD PhD

A terrific turnout with excellent projects from all corners of CV science MGH Cardiovascular Research Center and Mass General Heart. Congratulations to #CVRC2024 Retreat poster award winners Adam L. Johnson, Alok Kumar, Ph.D., Greg Gipson, and Shreya Sangam. Mentors Rajeev Malhotra David Sosnovik and Paul Yu MD PhD

Congratulations to Dr Sujin Lee of vascular surgery (and a fellow in my lab) for being a featured presenter at the MGB Women in Medicine & Science symposium! MGH Cardiovascular Research Center @MGH_RI

Check out our bioRxiv describing our efforts to treat a severe vascular disease 🫀: 1️⃣ Optimization of a target-specific base editor🧬 2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱 3⃣ Substantial extension of lifespan following in vivo base

Honored to be part of this incredible panel of scientists highlighting vascular calcification mechanisms & clinical implications. #AHA24 ⁦Elena Aikawa⁩ Linda Demer ⁦Josh Hutcheson⁩ Yabing Chen ⁦ATVB: An AHA Journal⁩ ⁦ATVB Council⁩ ⁦MGH Cardiovascular Research Center⁩

Speakers @ Vascular and Valvular Calcification: An ATVB/AHA Journals Session. #AHA24

Congratulations to Dr Sujin Lee in my lab for winning the MGH Outstanding Mentor Award & for her dedication to training the next generation of physician-basic scientists!! ⁦MGH Cardiovascular Research Center⁩ ⁦@MGH_RI⁩ ⁦Mass General Vascular⁩ ⁦Foundation Leducq⁩ Sujin Lee