Pubmed: Computational identification of cell-specific variable regions in ChIP-seq data. dlvr.it/RSCbVt

Different from that of the mammalian genome, Arabidopsis compartments seem to be driven solely by the nuclear lamina association and don't form compartment domains.

We are excited to share our recent work on Population-scale analysis of enhancer expression in the human brain. Welcome to comment and many thanks to all who were involved. Here are our key findings: biorxiv.org/content/10.110…

It's time to stop making t-SNE & UMAP plots. In a new preprint w/ Tara Chari we show that while they display some correlation with the underlying high-dimension data, they don't preserve local or global structure & are misleading. They're also arbitrary.🧵biorxiv.org/content/10.110…

Recent review from @LabRoussos and big congrats to Kiran Girdhar @majhemajhe pengfeiDong and @FullardJohn The Neuroepigenome: Implications of chemical and physical modification... sciencedirect.com/science/articl…

Thrilled to share our study in Nature Genetics on population-level analysis of transcribed enhancers. Thanks to my colleagues at @LabRoussos and reviewers for helping to improve it. nature.com/articles/s4158…

Please check out the preprint of our lab's new single-cell software, Dreamlet, a faster, memory-efficient statistical model for large-scale single-cell differential expression analysis.

We are thrilled to share a preprint on human myeloid cells and AD. Collaboration with Panos Roussos @FullardJohn Christian Porras @collin_spencer_ Milos Pjanic Philipp Weiler and many others.

The Center for Disease Neurogenomics (CDN) had a successful retreat day. The year 2024 marked the 10-year anniversary of the lab, and we have grown to 67 members. #CDN #retreat

🎉 Excited to announce preprints from the first #PsychAD package! Check out details of our work at Psych-AD.org 🧵 Found out summary of papers below👇

🧠 New brain atlas reveals region-specific gene regulation & promoter-isoform insights, advancing neuropsychiatric disorder research & genetic fine-mapping. #Genomics #Neuroscience #cdneurogenomics #roussoslab Read more in #NatureCommunications rdcu.be/d06ta

GET is finally published! - Paper: t.ly/iQct_ (new validations, dry and wet) - Model: t.ly/4jnUI (new tutorial on PBMC 10x Multiome data) - Analysis package: t.ly/OqLAL - Demo: t.ly/rbFQB - Docker: t.ly/86n_i

Excited to share our latest review in Trends in Genetics cell.com/trends/genetic…

Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6