The #immune system really puts the pressure on tumor cell diversity, clearing the cancerous environment of most tumor cell clones, Institut Pasteur, since 1887 scientists report in Science Immunology. bit.ly/2BxTR8a #cancer

Today, we take a look at NAD+ biology, its history, how it relates to aging, and the potential for therapies against age-related diseases via the NAD+ precursor molecule Nicotinamide mononucleotide (NMN). medium.com/lifespan-io/nm…

The translation of non-canonical open reading frames controls mucosal immunity disq.us/t/39g6udg

it is a mystery to me why a 2nd referendum (now that we know what Brexit would entail) would be a betrayal of democracy (as PM May claims) when the initial referendum, taken without knowing what Brexit would entail and against a backdrop of misleading predictions, was legitimate.

Our Cell Hashing work w/NYGCtech is out Genome Biology! Check out a few awesome experimental approaches for scRNA-seq multiplexing: - biorxiv.org/content/early/… (Lior Pachter) - biorxiv.org/content/early/… (Gartner Lab) - biorxiv.org/content/early/… (Samantha Morris) - genomebiology.biomedcentral.com/articles/10.11…

Optimizing gating strategies for facs

Senolytics are the first therapies that directly target one of the aging processes in order to delay or prevent age-related diseases, and they are now in human trials. Today, we think that it is the ideal time to have a look at how they work and what... medium.com/lifespan-io/th…

Having another read of this great piece of work (Graph abstraction).

Experimental design for in silico screening of perturbation response in the context of disease and drug treatment.

Our high-throughput enhancer-gene pair screen is officially published! In what we now (lovingly) refer to as "the assay formerly known as crisprQTL", we attempt at-scale validation and pairing of candidate regulatory elements with their target genes. 1/n cell.com/cell/fulltext/…

Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats aging-us.com/article/101683…

Interesting Financial Times. Quite optimistic after the past few years.

The bacteria in your gut may offer an accurate way to measure your biological age, according to a new study. leafscience.org/gut-bacteria-c…

First of many (hopefully) on studying ageing and neurodegeneration Tom Freeman McColl Lab Edinburgh. A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease onlinelibrary.wiley.com/doi/full/10.10…

With Fei Chen's lab, we introduce Slide-seq, for genome-wide expression profiling in tissue slices at 10-micron resolution. A single scientist can prepare dozens of slides in one day. Developed by two amazing students, Sam Rodriques and Bob Stickels. biorxiv.org/content/10.110…

First first author paper with McColl Lab Edinburgh and Anirudh Patir is published! 🥳👩‍🔬 Myeloid cell involvement and gene signature of inflammation resolution using a reductionist model of brain inflammation #neuroinflammation #microglia #trancsriptomics bit.ly/2VLcSuD

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension cell.com/cell-metabolis…

This is the most fun review I have read about the evolution of the immune system @CJASN "Imagine that you are a primitive animal, perhaps a distant predecessor of all mammals. You have lived a long life, thus far relying solely on a basic defence system." cjasn.asnjournals.org/content/10/7/1…

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity biorxiv.org/content/10.110…

Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis biorxiv.org/content/10.110…