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Online now! ✨RESEARCH: clinical outcomes differ between early- versus late-onset prostate cancer. Cheng et al explore the molecular differences using single cell and spatial transcriptomics on patient samples nature.com/articles/s4358… rdcu.be/ehjdy

🗞️Our April issue is live!📷 We're featuring work on immune aging, oligodendrocytes in aging & disease, single-cell resources, and news about exciting initiatives involved in biomarker development, geroscience, and autophagy research. Read it all here 👇 nature.com/nataging/volum…

Online now! The Berchowitz lab found that two retrotransposon-derived proteins, PNMA1 and PNMA4, support mammalian fertility in both sexes and become increasingly important during aging. (rdcu.be/eiT3z) doi.org/10.1038/s43587…

Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype. doi.org/10.1038/s43587…

Online now! Study presents FiNi-seq, a method that enriches fibrotic tissue based on its physical properties and captures aging-associated cell types to enable the characterization of early fibrotic changes. doi.org/10.1038/s43587…

What if the path to slowing aging wasn’t a drug, but replacing worn out parts? Our new paper out today in Nature Aging shows how this could one day work. We map a unified framework—from scaffolds & bioprinted tissues to pacemakers, xenotransplants & brain machine interfaces—for

🚨Just published in ⁦⁦Nature Aging⁩! 🧬 We discovered that a gut #microbiota-derived metabolite, phenylacetic acid (PAA), accumulates with age and triggers endothelial #senescence, a key driver of cardiovascular #aging. #Saeedi_Lab ➡️ Read more nature.com/articles/s4358…

Join us, Nature Neuroscience and Nature Metabolism in Daegu, South Korea, Dec 9-11 for a Nature Conference on brain aging: Towards Healthy Brain Aging: Bridging Biology, Lifestyle, and Therapeutics, in partnership with DGIST - natureconferences.streamgo.live/towards-health…

Online now! Using real-world intrinsic capacity (IC) screening data from implementation of WHO ICOPE program in primary care, de Souto Barreto, Lu et al., developed clinically friendly IC scores and centile values to monitor functional health during aging. doi.org/10.1038/s43587…

Online now! Rowan Saloner et al. used large-scale CSF proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression. UCSF MAC ALLFTD doi.org/10.1038/s43587…

Online now!✨RESEARCH: Tu, Qian et al identify BAZ2B as an epigenetic regulator of hepatocyte senescence, linking liver aging to MASH through PPARα and lipid metabolism nature.com/articles/s4358… rdcu.be/emMr4

Online now! The authors identify, in a cohort of patients undergoing preimplantation genetic testing for aneuploidy, H3K27ac loss as a hallmark of endometrial aging linked to endometrial receptivity. (rdcu.be/em7mT) doi.org/10.1038/s43587…

Online now! Guo et al., identify human antigen R (HuR) as a regulator of age-related hearing loss (ARHL) in aged mice, and demonstrates that cochlear HuR overexpression alleviates ARHL, highlighting it as a therapeutic target for the condition. doi.org/10.1038/s43587…