Our latest publication together with @SchneiderG_Dr lab in EMBO Mol. Medicine: Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems embopress.org/doi/full/10.15… Maximilian Reichert @sfb1321 TU München 1/4

New paper resulting from a large collaborative effort btwn brekken/minna/fu/li labs @UTSWNews, UTSW Simmons Cancer Center. Lead author is another outstanding UTSWCancerBio trainee. cell.com/cell-reports-m…

Our recent paper in Cancer Research highlights the unique vulnerabilities of "arid" and "fertile" #PancreaticCancer domains: Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer. #metabolomics ncbi.nlm.nih.gov/pubmed/35315913

If you are interested in apCAFs in PDA give this paper from Huocong Huang a read. UTSW Simmons Cancer Center UTSWCancerBio UTSW Surgery He had wonderful help from TurleyLab Mesothelial cell-derived antigen-presenting cancer-associated fibrobla... sciencedirect.com/science/articl…

ICYMI: Final version of the Cancer Discovery paper on T cell trajectories in pancreatic cancer is now online. Magnum opus from the MD Anderson Cancer Center #PancreaticCancer #Moonshot team. Single cell RNAseq & TCRseq on 80,000 T cells, treasure trove for mining targets! aacrjournals.org/cancerdiscover…

Todd Aguilera MD PhD Dr. Nina Niu Sanford David Palma, MD, PhD Ali Hosni @TAMERMR Laura Dawson Robert Timmerman A series of SABR ttt PDAC oligomets (OPanc) (1-5 mets) published in Red Journal. Retro, small n & selection bias limiting, but SABR doubled OS with less time on CTH. authors.elsevier.com/c/1fgzw1Hx52CH…

Excited to share our latest work highlighting the role of cell competition in shaping metastatic latency and relapse Cancer Discovery !! A collaborative effort with Payal Kapur James Brugarolas and Brekkenlab Elizabeth McKenna - Appreciate all the support !!

Pleiotrophin drives a prometastatic immune niche in #BreastCancer, say Debolina Ganguly Debolina Ganguly, Rolf Brekken Brekkenlab et al UTSW Simmons Cancer Center @UTSWNews: bit.ly/3IRSdB9 @gilbertzmurimwa Fatima Valdes Mora David Gallego Ortega #TumorImmunology #metastasis

"This work has opened the door for a decade’s worth of research." -timofran Michigan Medicine & Gift of Life Michigan project shows PanIN lesions more common than previously thought, opening new pathway to understanding progression of pancreatic cancer. ⬇️⬇️⬇️ medicine.umich.edu/dept/surgery-r…

Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – discovered that base-modified mRNA can be used to block activation of inflammatory reactions and increase protein production when mRNA is delivered to cells.

How does the location of a tumor influence #healthoutcomes? Check out UT Southwestern Internal Medicine researcher and #NIHHighRisk New Innovator Awardee Dr. Ravikanth Maddipati and his work to better understand #cancer. UTSW Media Relations utsouthwestern.edu/newsroom/artic…

Early-stage investigators proposed innovative high-impact research ideas for the NIH Director’s New Innovator Award. See the projects the awardees will pursue: commonfund.nih.gov/newinnovator/A… #NIHHighRisk

Excited to be one of the NIH New Innovator Award recipients! It is an honor and privilege to be in the company of so many innovative young scientists. Looking for good post-docs to help carry the project forward! x.com/NIH_CommonFund…

Conventional therapies often fail in metastatic pancreatic cancer. Maddipati Lab UTSW Simmons Cancer Center reviews tumor-stroma interactions that shape metastatic progression in PDAC and highlight potential stage- and site-specific therapeutic opportunities for intervention: