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A good read on PRS/PGS.

This faculty opportunity is across biomedical informatics domains but please ask me about the extraordinary opportunities in Precision Medicine and Translational Bioinformatics at Vanderbilt Health @vumcdbmi

Out in AJHG - large-scale return of sequencing results for >16,000 participants shows 44% received services in 1 year and modest mean $ increase in labs, procedures ($149). Many thanks to all our collaborators! doi.org/10.1016/j.ajhg… @JacksonJodell @eMERGENetwork_

Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect? YES! Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans Clinical implication: It’s early

Data driven science and diversity in the AllofUsResearch program: An informative summary by Josh Denny @PersonalizedMed and @SheriSchully. Via Science Translational Medicine science.org/doi/10.1126/sc…

Join us for a panel on Challenges of Remote #Data #Harmonization and Querying at #PMWC24. Speaking are Heidi Rehm, Chris Lunt NIH, Simona Carini UC San Francisco, Josh Peterson and others! Details: Jan 26, 9:30 A.M. Track 2. More at pmwcintl.com/program.

Pleased that the RISE project is represented. Josh Peterson Geisinger Research Jing Hao

The diagnostic odyssey is real in rare genetic conditions. Standardized #diagnosticdelay measurement & inclusion of low-income countries in diagnostic delay research are needed to develop systematic solutions bit.ly/3HCKV2s @rozatinker Josh Peterson Lisa Bastarache

Excited to share AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in nature nature.com/articles/s4158…

Exciting news! 🎉 Five peer-reviewed articles showcasing the power of the AllofUsResearch Program dataset have been published today in nature journals. I’ll be taking a closer look at each over the next few days. Read the announcement: allof-us.org/49uGfYM

A huge eMerge Network effort to develop, validate, and clinically report PRS is now out in Nature Medicine nature.com/articles/s4159…

Excited to share our manuscript in Nature Communications looking at the clinical consequences of a polygenic predisposition to benign lower white blood cell (WBC) counts. @VUMCgenetics @VUMC_Medicine @vumcdbmi @VUMCHemOnc doi.org/10.1038/s41467…

A Nature Genetics study, led by @VUMC_Cancer researchers, sheds light on some of the genetic variants that make #breastcancer more deadly for women of African ancestry and reduces the disparity in knowledge for assessing their genomic risk factors. spr.ly/6010d1xcp

Congrats to Jonathan Mosley, John Shelley and coauthors on another key study on how genetics help interpret laboratory values news.vumc.org/2024/06/03/gen…

Please join us for NHLBI's 2-day virtual workshop “Return of Individual Research Results to Participants in Observational Cohort Studies” June 26-27.   Focuses on incidental genomic results Link for the agenda & registration below tinyurl.com/tru8es3t NIH NHLBI NHGRI

Excited to share our paper published in Metabolism - Clinical and Experimental Congrats Jane F Ferguson Jonathan Mosley @JaneFreedmanMD metabolismjournal.com/article/S0026-…

A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In Nature Medicine led by Joseph Breeyear Jacklyn Hellwege Ayush Giri Todd Edwards Vanderbilt University Medical Center nature.com/articles/s4159…

AGBT Meeting Anne O'Donnell-Luria and I are very excited to offer this pre-conference workshop on genomic databases. Come join us at AGBT Meeting Precision Health!

I am honored and thrilled to take on the role of Division Director for Genetic Medicine VUMC Department of Medicine! As a junior faculty member, I benefited tremendously from mentorship and support from Nancy J Cox. I look forward to paying it forward Vanderbilt Genetics Institute!

Celebrating achievement of target enrollment in eMERGE IV at the Consortium meeting in DC ~25,000 enrolled (~20,000 adults, ~5000 children) in a study of returning polygenic risk scores in the clinical setting ~48% belong to health disparity groups ⁦⁦Eric Green⁩