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A multimorphic variant in ThPOK causes #InbornErrorsOfImmunity with T cell defects and #fibrosis, say Maryam Vaseghi-Shanjani (Maryam Vaseghi-Shanjani), Mehul Sharma, Catherine M. Biggs, Stuart E. Turvey et al. Turvey lab hubs.la/Q03nlKfG0

.Ahmed Kabil, Hughes, KMcNagny-Lab, Biomedical Miracles at work et al. identify a balance between ILC2s & ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes #fibrosis, while ILC3 depletion protects against it. hubs.la/Q03pvv_H0 #MucosalImmunology

So proud of Ahmed and the Team for their hard work on Crohn's-like fibrosis UBC Media Relations Canadian Society for Immunology STEMCELL Technologies Stem Cell Network CIHR-III | IRSC-IMII @EMBL ImmunoT AllerGen Network UBC School of Biomedical Engineering Crohn's & Colitis Foundation Beyond Celiac HLI at St Paul's

Fike, Rahman et al. describe mechanisms of IRF7-driven #autoimmune B cell and autoantibody responses. They reveal that IRF7 promotes #lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells. hubs.la/Q03pLc6k0

ILC2 are critical regulators of #inflammation and tissue homeostasis in diverse anatomical sites. timhalim Cancer Research UK highlights work by Kabil et al (hubs.la/Q03pLb6R0) which developed a novel mouse line to study the role of Rora in mature ILC2 hubs.la/Q03pLbPR0

#OTD in 1928, Rockefeller's Rebecca Lancefield upended the field of microbiology when she reported in Journal of Experimental Medicine the discovery of M protein, a virulence factor that grants streptococcus bacteria the ability to dodge the body's natural defenses. Read it here: pubmed.ncbi.nlm.nih.gov/19869450/

The cover of our June issue (hubs.la/Q03pvHwm0) shows a whole tumor formed after subcutaneous injection of a 1:1 mixture of CIT6-YFP (yellow) and CIT9-RFP (red) cell lines into mice carrying an inactivated Confetti cassette. From Tanaka et al. (hubs.la/Q03pvBtr0)

New review from Natalia Reglero Real, Loïc Rolas, and Sussan Nourshargh Lab explores how #aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic #inflammation. hubs.la/Q03q8nRg0

Check out our review on #aging microvasculature and immune cell trafficking!

Thrilled to have our latest review published in Journal of Experimental Medicine! A huge thank you to Natalia Reglero Real and Sussan Nourshargh Lab , our teamwork made this possible. Looking forward to the discussions ahead! #aging #bloodvessel British Heart Foundation

Rica, Waldherr, Miyakoda, Sakaguchi et al. MedUni Wien show that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells hubs.la/Q03qLX5l0

Frolov, Huang et al. show that #microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. hubs.la/Q03pZMK30 📘 From #Neuroimmunology and #Neurodegeneration 2025: hubs.la/Q03pZLsW0

Wen, Ralph Weichselbaum et al. review how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair & the immune microenvironment & discuss their potential as therapeutic targets to enhance the efficacy of radiotherapy & #immunotherapy hubs.la/Q03qTwbh0

Filamin A editing in myeloid cells reduces intestinal #inflammation and protects from #colitis, say Riem Gawish, Fatima Pereira, Cornelia Vesely (Conny Vesely) and colleagues MedUni Wien Anatomy and Cell Biology (CACB) MedUniVienna: hubs.la/Q03qTLsr0 #MucosalImmunology #InnateImmunity

Great work by great team very lucky

We are hiring! JEM seeks an Executive Editor to lead our editorial team in NYC. Responsibilities include guiding journal strategy, managing an editorial team, engaging with researchers, and more. Apply here 👉 hubs.la/Q03qZj-L0 #STMjobs #PublishingJobs #ScienceJobs

So happy and thankful to all that contributed to this project. Freshly out now in JEM.

Fonta et al show that oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity. IL-33 ablation reduces persistence & TCF-1low effector T cell generation hubs.la/Q03pZMK20 📘In #Neuroimmunology & #Neurodegeneration 2025 hubs.la/Q03pZNPg0

Kun Peng, Yang-Xin Fu, Yong Liang et al. Tsinghua University highlight that next-generation mRNA #vaccines encoding membrane-tethered #cytokine adjuvants can generate potent pre-effector cells offering effective tumor control with reduced toxicity. hubs.la/Q03r3NVY0