Transcriptional network dynamics in early T cell development. A new review from Boyoung Shin (boyoungshin), Ellen Rothenberg (@EVRlab) and colleagues Caltech: hubs.la/Q02M3Nbp0 #Thymus #TcellDevelopment #Hematopoiesis; #StemCells #Regeneration #LymphocyteBiology #Notch

Tumor cell–intrinsic Piezo2 drives #radioresistance by impairing CD8+ T cell stemness maintenance, say Naijun Miao, Dongqing Cao, Jingsi Jin, Fan Xia, Wenwen Li and colleagues (Shanghai Jiao Tong University School of Medicine) hubs.la/Q02M3HBK0 #TumorImmunology #Cancer

Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our 14th CME Activity MSK CME is NOW available 👉 hubs.la/Q02DJtVh0

Doye, Chaintreuil, Lagresle-Peyrou, Laurent Boyer Université Côte d'Azur et al. show NLRP3 #inflammasome activation in circulating myeloid cells by human RAC2 gain-of-function variants that are linked to rare immune disorders. hubs.la/Q02N9s2m0 #HumanDiseaseGenetics #Immunodeficiency

The pursuit of a #vaccine to quell #Staphylococcus aureus disease has been unfruitful. @stephaureuslab and Wardenburg Test Account explore the biological linkage between microbial niche acquisition and host immunity as a basis to guide future vaccine efforts. hubs.la/Q02Lznq80

.Irem:), Watson, Russell Jones Van Andel Institute (VAI) and colleagues show that ACLY and ACSS2 coordinate cytosolic acetyl-CoA production in CD8 T cells to maintain #chromatin accessibility and T cell effector function. hubs.la/Q02LHTkY0 #Metabolism #LymphocyteBiology

.Nikos Angelis, Baulies et al. Vivian Li suggest that Arid3a functions to fine-tune the proliferation–differentiation dynamics at the TA progenitors, which are essential for injury-induced regeneration in the intestine. hubs.la/Q02LHzY_0 #StemCells #Regeneration

Very happy and proud to share our latest work JExpMed, a fantastic collaboration Institut Imagine C3M #amazingteamwork hubs.la/Q02N9s2m0 Université Côte d'Azur Inserm Inserm Provence-Alpes-Côte d'Azur et Corse CHU de Nice ANR

Our September issue is out! hubs.la/Q02N4DBR0 The cover shows hPSC-derived hindbrain neurons derived from a patient with IFNAR1 complete deficiency pretreated with IFN-β and infected with SARS-CoV-2. From Yi-Hao Chan Lab, Shen-Ying Zhang et al. (hubs.la/Q02N4zQm0)

Amazing!! What a pleasant surprise to be featured on the cover of JExpMed! (: please read our paper in collaboration with #CHGE here: dx.doi.org/10.1084/jem.20…

In our latest #PeopleAndIdeas, Lucie Van Emmenis spoke to Sarah Gaffen (@SLG1717) PittRheum University of Pittsburgh about where her interest in #cytokines began, the importance of saying no in your career, and her interest in #paleogenetics. hubs.la/Q02LK7sz0

Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer. New study from Apostolia Tsimberidou, Farah Alayli, Kwame Okrah, Padmanee Sharma Padmanee (Pam) Sharma, MD, PhD and colleagues MD Anderson Cancer Center Parker Institute for Cancer Immunotherapy: hubs.la/Q02MKXkK0

Miao, Cao, Jin et al. reveal that tumor cell–intrinsic Piezo2 induces #radioresistance by dampening the IRF-1/IL-15 axis, thus leading to impaired CD8+ T cell–dependent antitumor responses hubs.la/Q02M3NQD0 #SolidTumors #TumorImmunology #cancer

Don't miss this inspiring interview to ICIS president Sarah Gaffen (Gaffen Lab 17 (Dr. Sarah Gaffen)) by Lucie Van Emmenis 😉

.boyoungshin, Rothenberg @EVRlab et al. Caltech review how the dynamic interplay between #Notch signals, Notch-induced factors, and progenitor-associated factors control T-development progression by synergizing and opposing each other’s action. hubs.la/Q02M3MZt0 #Thymus

.Wan-Lin Lo and Huseby review how thymic selection matures or eliminates clonotypes w/ particular specificities and develops T cell sublineages and microrepertoires according to their antigen-recognition capabilities. hubs.la/Q02M3MC_0 #TcellDevelopment #Thymus

Pala, Notarangelo, & Bosticardo NIAID News discuss new advancements that offer unprecedented insights into thymic biology and hold promise for the development of novel therapeutic strategies for immune-related disorders. hubs.la/Q02M2JWq0 #Thymus #TCellDevelopment

Our latest #CME activity MSK CME is now available! New content: “SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma” by H. Guido Wendel Lab @ MSKCC (hubs.la/Q02NPb930) Begin the CME here 👉 hubs.la/Q02NPp3t0

SETD1B (KMT2G) is a #histone H3K4 trimethyl transferase & a mutational target in #lymphoma. Ana Portelinha, Wang, Parsa et al H. Guido Wendel Lab @ MSKCC Memorial Sloan Kettering Cancer Center show that SETD1B inactivation disables critical cell death programs and causes Venetoclax resistance. hubs.la/Q02NQ0DP0

Hahn, Parks, Shen, McElrath et al. Fred Hutchinson Cancer Center UW Medicine present data from a first-in-human #HIV vaccine trial with a novel TLR-7/8-signaling adjuvant (3M-052AF/Alum). hubs.la/Q02NQ9Fy0 #InfectiousDisease #HostDefense #Virology