
Journal of Experimental Medicine
@jexpmed
The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress
ID: 75302402
http://www.jem.org 18-09-2009 15:08:42
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A multimorphic variant in ThPOK causes #InbornErrorsOfImmunity with T cell defects and #fibrosis, say Maryam Vaseghi-Shanjani (Maryam Vaseghi-Shanjani), Mehul Sharma, Catherine M. Biggs, Stuart E. Turvey et al. Turvey lab hubs.la/Q03nlKfG0


.Ahmed Kabil, Hughes, KMcNagny-Lab, Biomedical Miracles at work et al. identify a balance between ILC2s & ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes #fibrosis, while ILC3 depletion protects against it. hubs.la/Q03pvv_H0 #MucosalImmunology


So proud of Ahmed and the Team for their hard work on Crohn's-like fibrosis UBC Media Relations Canadian Society for Immunology STEMCELL Technologies Stem Cell Network CIHR-III | IRSC-IMII @EMBL ImmunoT AllerGen Network UBC School of Biomedical Engineering Crohn's & Colitis Foundation Beyond Celiac HLI at St Paul's



#OTD in 1928, Rockefeller's Rebecca Lancefield upended the field of microbiology when she reported in Journal of Experimental Medicine the discovery of M protein, a virulence factor that grants streptococcus bacteria the ability to dodge the body's natural defenses. Read it here: pubmed.ncbi.nlm.nih.gov/19869450/



New review from Natalia Reglero Real, Loïc Rolas, and Sussan Nourshargh Lab explores how #aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic #inflammation. hubs.la/Q03q8nRg0



Thrilled to have our latest review published in Journal of Experimental Medicine! A huge thank you to Natalia Reglero Real and Sussan Nourshargh Lab , our teamwork made this possible. Looking forward to the discussions ahead! #aging #bloodvessel British Heart Foundation

Rica, Waldherr, Miyakoda, Sakaguchi et al. MedUni Wien show that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells hubs.la/Q03qLX5l0



Wen, Ralph Weichselbaum et al. review how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair & the immune microenvironment & discuss their potential as therapeutic targets to enhance the efficacy of radiotherapy & #immunotherapy hubs.la/Q03qTwbh0


Filamin A editing in myeloid cells reduces intestinal #inflammation and protects from #colitis, say Riem Gawish, Fatima Pereira, Cornelia Vesely (Conny Vesely) and colleagues MedUni Wien Anatomy and Cell Biology (CACB) MedUniVienna: hubs.la/Q03qTLsr0 #MucosalImmunology #InnateImmunity






Kun Peng, Yang-Xin Fu, Yong Liang et al. Tsinghua University highlight that next-generation mRNA #vaccines encoding membrane-tethered #cytokine adjuvants can generate potent pre-effector cells offering effective tumor control with reduced toxicity. hubs.la/Q03r3NVY0
