Journal of Experimental Medicine (@jexpmed) 's Twitter Profile
Journal of Experimental Medicine

@jexpmed

The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress

ID: 75302402

linkhttp://www.jem.org calendar_today18-09-2009 15:08:42

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Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

A multimorphic variant in ThPOK causes #InbornErrorsOfImmunity with T cell defects and #fibrosis, say Maryam Vaseghi-Shanjani (Maryam Vaseghi-Shanjani), Mehul Sharma, Catherine M. Biggs, Stuart E. Turvey et al. Turvey lab hubs.la/Q03nlKfG0

A multimorphic variant in ThPOK causes #InbornErrorsOfImmunity with T cell defects and #fibrosis, say Maryam Vaseghi-Shanjani (<a href="/vaseghi_maryam/">Maryam Vaseghi-Shanjani</a>), Mehul Sharma, Catherine M. Biggs, Stuart E. Turvey et al. <a href="/TurveyLab/">Turvey lab</a>  
hubs.la/Q03nlKfG0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

.Ahmed Kabil, Hughes, KMcNagny-Lab, Biomedical Miracles at work et al. identify a balance between ILC2s & ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes #fibrosis, while ILC3 depletion protects against it. hubs.la/Q03pvv_H0 #MucosalImmunology

.<a href="/ahmed_kabilAK/">Ahmed Kabil</a>, Hughes, <a href="/KMcNagnylab/">KMcNagny-Lab, Biomedical Miracles at work</a> et al. identify a balance between ILC2s &amp; ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes #fibrosis, while ILC3 depletion protects against it. hubs.la/Q03pvv_H0 

#MucosalImmunology
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Fike, Rahman et al. describe mechanisms of IRF7-driven #autoimmune B cell and autoantibody responses. They reveal that IRF7 promotes #lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells. hubs.la/Q03pLc6k0

Fike, Rahman et al. describe mechanisms of IRF7-driven #autoimmune B cell and autoantibody responses. They reveal that IRF7 promotes #lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells. hubs.la/Q03pLc6k0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

ILC2 are critical regulators of #inflammation and tissue homeostasis in diverse anatomical sites. timhalim Cancer Research UK highlights work by Kabil et al (hubs.la/Q03pLb6R0) which developed a novel mouse line to study the role of Rora in mature ILC2 hubs.la/Q03pLbPR0

ILC2 are critical regulators of #inflammation and tissue homeostasis in diverse anatomical sites. <a href="/timotheus_halim/">timhalim</a> <a href="/CR_UK/">Cancer Research UK</a> highlights work by Kabil et al (hubs.la/Q03pLb6R0) which developed a novel mouse line to study the role of Rora in mature ILC2 hubs.la/Q03pLbPR0
Rockefeller University (@rockefelleruniv) 's Twitter Profile Photo

#OTD in 1928, Rockefeller's Rebecca Lancefield upended the field of microbiology when she reported in Journal of Experimental Medicine the discovery of M protein, a virulence factor that grants streptococcus bacteria the ability to dodge the body's natural defenses. Read it here: pubmed.ncbi.nlm.nih.gov/19869450/

#OTD in 1928, Rockefeller's Rebecca Lancefield upended the field of microbiology when she reported in <a href="/JExpMed/">Journal of Experimental Medicine</a> the discovery of M protein, a virulence factor that grants streptococcus bacteria the ability to dodge the body's natural defenses. Read it here: pubmed.ncbi.nlm.nih.gov/19869450/
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

The cover of our June issue (hubs.la/Q03pvHwm0) shows a whole tumor formed after subcutaneous injection of a 1:1 mixture of CIT6-YFP (yellow) and CIT9-RFP (red) cell lines into mice carrying an inactivated Confetti cassette. From Tanaka et al. (hubs.la/Q03pvBtr0)

The cover of our June issue (hubs.la/Q03pvHwm0) shows a whole tumor formed after subcutaneous injection of a 1:1 mixture of CIT6-YFP (yellow) and CIT9-RFP (red) cell lines into mice carrying an inactivated Confetti cassette. From Tanaka et al. (hubs.la/Q03pvBtr0)
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

New review from Natalia Reglero Real, Loïc Rolas, and Sussan Nourshargh Lab explores how #aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic #inflammation. hubs.la/Q03q8nRg0

New review from <a href="/NatReglero/">Natalia Reglero Real</a>, <a href="/LoicRolas/">Loïc Rolas</a>, and <a href="/NoursharghLab/">Sussan Nourshargh Lab</a> explores how #aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic #inflammation. hubs.la/Q03q8nRg0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Rica, Waldherr, Miyakoda, Sakaguchi et al. MedUni Wien show that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells hubs.la/Q03qLX5l0

Rica, Waldherr, Miyakoda, Sakaguchi et al. <a href="/MedUni_Wien/">MedUni Wien</a> show that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells hubs.la/Q03qLX5l0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Frolov, Huang et al. show that #microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. hubs.la/Q03pZMK30 📘 From #Neuroimmunology and #Neurodegeneration 2025: hubs.la/Q03pZLsW0

Frolov, Huang et al. show that #microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. hubs.la/Q03pZMK30

📘 From #Neuroimmunology and #Neurodegeneration 2025: hubs.la/Q03pZLsW0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Wen, Ralph Weichselbaum et al. review how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair & the immune microenvironment & discuss their potential as therapeutic targets to enhance the efficacy of radiotherapy & #immunotherapy hubs.la/Q03qTwbh0

Wen, <a href="/rweichselbaum/">Ralph Weichselbaum</a> et al. review how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair &amp; the immune microenvironment &amp; discuss their potential as therapeutic targets to enhance the efficacy of radiotherapy &amp; #immunotherapy  hubs.la/Q03qTwbh0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Filamin A editing in myeloid cells reduces intestinal #inflammation and protects from #colitis, say Riem Gawish, Fatima Pereira, Cornelia Vesely (Conny Vesely) and colleagues MedUni Wien Anatomy and Cell Biology (CACB) MedUniVienna: hubs.la/Q03qTLsr0 #MucosalImmunology #InnateImmunity

Filamin A editing in myeloid cells reduces intestinal #inflammation and protects from #colitis, say Riem Gawish, Fatima Pereira, Cornelia Vesely (<a href="/ConnyVes/">Conny Vesely</a>) and colleagues <a href="/MedUni_Wien/">MedUni Wien</a> <a href="/CenterCACB/">Anatomy and Cell Biology (CACB) MedUniVienna</a>: hubs.la/Q03qTLsr0

#MucosalImmunology #InnateImmunity
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

We are hiring! JEM seeks an Executive Editor to lead our editorial team in NYC. Responsibilities include guiding journal strategy, managing an editorial team, engaging with researchers, and more. Apply here 👉 hubs.la/Q03qZj-L0 #STMjobs #PublishingJobs #ScienceJobs

We are hiring! JEM seeks an Executive Editor to lead our editorial team in NYC. Responsibilities include guiding journal strategy, managing an editorial team, engaging with researchers, and more. Apply here 👉 hubs.la/Q03qZj-L0 

#STMjobs #PublishingJobs #ScienceJobs
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Fonta et al show that oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity. IL-33 ablation reduces persistence & TCF-1low effector T cell generation hubs.la/Q03pZMK20 📘In #Neuroimmunology & #Neurodegeneration 2025 hubs.la/Q03pZNPg0

Fonta et al show that oligodendrocyte-derived IL-33 regulates self-reactive CD8⁺ T cells in CNS autoimmunity. IL-33 ablation reduces persistence &amp; TCF-1low effector T cell generation hubs.la/Q03pZMK20

📘In #Neuroimmunology &amp; #Neurodegeneration 2025 hubs.la/Q03pZNPg0
Journal of Experimental Medicine (@jexpmed) 's Twitter Profile Photo

Kun Peng, Yang-Xin Fu, Yong Liang et al. Tsinghua University highlight that next-generation mRNA #vaccines encoding membrane-tethered #cytokine adjuvants can generate potent pre-effector cells offering effective tumor control with reduced toxicity. hubs.la/Q03r3NVY0

Kun Peng, Yang-Xin Fu, Yong Liang et al. <a href="/Tsinghua_Uni/">Tsinghua University</a> highlight that next-generation mRNA #vaccines encoding membrane-tethered #cytokine adjuvants can generate potent pre-effector cells offering effective tumor control with reduced toxicity. hubs.la/Q03r3NVY0