Heterozygous familial hypercholesterolemia is a common genetic condition characterised by high LDL cholesterol levels from a young age. A new Review discusses the contemporary knowledge of familial hypercholesterolaemia and its unmet clinical needs: hubs.li/Q03QmHhS0

Evaluación no invasiva de la fibrosis hepática. NEJM nejm.org/doi/10.1056/NE… SEEDO EHMETSEEN GT-SEMI Diabetes, Obesidad y Nutrición #17DM_SEMI GT Riesgo Vascular SEMI Medicina Interna HCSBA #46SEMI Sociedad Española de Medicina Interna M Shafi Kuchay Fernando Alcívar

New insights on assessing LIVER FIBROSIS with NON-INVASIVE TESTS, just released by NEJM: - Key techniques & thresholds. - Practical algorithms & actionable steps. shorturl.at/amz1p

🧬 New research alert: Comparison of PREVENT Score versus the Pooled Cohort Equation for estimating ASCVD risk in patients with Rheumatoid Arthritis. Explore the full study 👉 ow.ly/zrxH50XjT5h #Cardiology #RA #ASCVD #RiskPrediction #PreventiveCardiology

LDL-ApoB discordance ⚖️ ➡️ most pronounced in metabolically unhealthy obesity ➡️ metabolic dysfunction, more than obesity, drives increased apoB–LDL-C discordance lipidjournal.com/article/S1933-…

rdm.ox.ac.uk/about/our-faci…

GLP-1 drugs have intrinsic potent anti-inflammatory action beyond their metabolic beneficial impact on glucose regulation and weight loss Daniel J Drucker Journal of Clinical Investigation jci.org/articles/view/…

🔰Patobiología de la prediabetes. 🤓Esta revisión analiza la transición desde la regulación normal de la glucosa, pasando por la disglucemia hasta llegar a prediabetes. 👍Evalúa factores de riesgo, complicaciones y estrategias de tratamiento. doi.org/10.2337/dbi25-… 𝘋𝘳𝘢. 𝒜𝒞 ⚕🪬

Myth busted: New evidence confirms — lowering LDL does not increase the risk of hemorrhagic stroke.

En este metanálisis con 58 816 pacientes usuarios de iSGLT2, agrupados en grupos con DM y sin DM, RAC ≥ 200 mg o < 200 mg/g. 🎯Se evidencio beneficios absolutos en eficacia renal, menor hospitalización y mortalidad independiente de tener o no DM, o de tener albuminuria mayor o

Combo triple agonist for FGF21 R/ Glucagon R/ GLP1 R lowers triglycerides by 69% v placebo among individuals with severe hypertriglyceridemia in a ph2 trial of N=79 #AHA25

How many birds are there?

Yes, it's possible. As I wrote in Super Agers regarding expansion of healthspan. nature.com/articles/s4158… Nature Biotechnology

"Worsening versus advanced #HeartFailure: Management and challenges" - Check out the article in #ESCHeartFailure ow.ly/Y8Wh50XoaB2 EJHF Editor-in-Chief Jan Biegus @Ppponikowski #HFA_ESC Harriette Van Spall, MD MPH 🇨🇦 Shelley Zieroth Marat Fudim, MD MHS Gregg Fonarow MD Alexandre Mebazaa Marco Metra Gianluigi Savarese Holger Thiele

🚀 Calcium Score & CCTA: Key Highlights from the 2025 AHA Scientific Statement (DOI: 10.1161/CIR.0000000000001394) Non-obstructive CAD in Chest Pain Patients 🧊 1. CAC = Atherosclerotic Burden, Not Just a Number CAC is one of the strongest predictors of future ASCVD risk—better

Exciting to see Merck's enlicitide (oral PCSK9 inhibitor) continue to show very high LDL-C-lowering efficacy (~ -60%) now in multiple trials jamanetwork.com/journals/jama/… JAMA AHA Science #AHA25 Enlicitide is an important pharmacologic success that has key innovations to

There's a big shift in cardiology to the high-risk, non-obstructed, inflamed artery and reducing heart attacks erictopol.substack.com/p/the-big-shif…

Ecografía para detectar resistencia a la insulina Es momento de abandonar la glucemia como marcador de enfermedad Y la IA llegó para ayudarnos a llegar 10 años antes Ecografía muscular y diagnóstico de resistencia a insulina

New paper: Risk matters for ASCVD — but vascular resilience may decide the outcome. Insightful work by Michael D. Shapiro and Khurram Nasir on why not all high-risk patients experience events. ow.ly/6cfj50XxfnQ #CardioResearch #VascularResilience #PreventiveCardiology @aspcardio

Check out the 2025 highlights from ASPC — a deep dive into evolving strategies in cardiovascular disease prevention. ⚙️❤️‍🩹 ow.ly/cMWH50XAYeN Annalisa Filtz Michael D. Shapiro Fatima Rodriguez Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Ron Blankstein Dr. Deepak L. Bhatt Clyde Yancy, MD, MSc Leandro Slipczuk