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Clinical trials are underway to evaluate novel agents targeting the alternative complement pathway in patients with C3G. Kidney Health Initiative's C3G Trial Endpoints Work Group assessed prespecified endpoints as measures of clinical benefit in these trials bit.ly/CJASN0505

Fantastic for RaDaR team to work with registries, stakeholders and experts from multiple countries to catalyse clinical trials in a rare kidney disease. Go Team Kidney!

Yesterday The Labour Party published its manifesto. We welcome a number of their commitments including to develop an NHS innovation and adoption strategy in England to include faster regulatory approval for new technologies and medicines #GeneralElection2024

Delighted to share our latest research using multiscale topology to classify cells in subcellular spatial kidney transcriptomic data nature in collaboration with Heather Harrington Katherine Benjamin Oxford Mathematics nature.com/articles/s4158…

Two weeks to go until our Alport Research Hub Symposium where professors Rachel Lennon, Prof Danny Gale and Neil Turner discuss the latest news and approaches to Alport syndrome. Not registered? Click here: bit.ly/3xjv8o2 Alport UK

In 2001 KDOQI said all kidney patients had the same disease, CKD, and we should differentiate them based solely on GFR. This was never true, and this study does a wonderful job exposing the lie. #nephjc (Me channeling Melanie Hoenig who taught me this)

Look at the beautiful visual abstract made by Brian Rifkin, MD🎨 #NephJC nephjc.com/news/2024/7/9/…

8 days left to apply! This second call welcomes research ideas that could help us to understand the impact that Alport syndrome has on hearing and sight as well as kidney problems. Find out more and apply here: bit.ly/3PG99OQ Closes 4 Sept. Prof Danny Gale Rachel Lennon

Fantastic to see this #statisticalgenetics tour de force by Omid S. Alavijeh using Genomics England #WGS to explore #ADPKD #ARPKD out in Journal of Clinical Investigation 🧬 Novel associations with COL4A3 and monoallelic PKHD1 variants 🧬 3-9% heritability explained by common variants

Well done Omid Omid S. Alavijeh - great to see this published!

Increased risk of kidney failure in patients with genetic kidney disorders CureGN pubmed.ncbi.nlm.nih.gov/39225089/

Delighted to share our latest Greka Lab story in collaboration with Prof. Hao Wu on the molecular basis of TMED9 cargo receptor oligomerization and entrapment of misfolded cargo in the early secretory pathway. Broad Institute Harvard Medical School Mass General Brigham science.org/doi/10.1126/sc…

This is a tragic and devastating loss to UCL, the Royal Free Hospital, RaDaR and the renal community everywhere. It is a particular loss to his patients for whom he was such a champion. My thoughts and deepest condolences are with his family at this terrible time.

The fantastic Laura Mariani revealing data-derived trial endpoint proposals to allow feasible clinical trials in #FSGS #ParasolProject International Society of Glomerular Disease

This comprehensive analysis of variants in cystic kidney disease leveraged 100,000 genomes! jci.org/articles/view/… @Oalavijeh Prof Danny Gale & team highlight the contributions to disease risk of different types of variants across the allelic spectrum.

PARASOL news from the Scientific Workshop with U.S. FDA. Stay tuned for more updates at #KidneyWk2024! (translational session at 4:30 Friday 10/25) #FSGS #KidneyHealth #ResearchRevolution eu1.hubs.ly/H0d2BZl0 NephCure National Kidney Foundation Michigan Kidney Translational Med. Center (MiKTMC) American Society of Nephrology

Just published in JASN_News - our long-term outcome analysis of rituximab in podocytopathies: journals.lww.com/jasn/abstract/… A special thank you to my partner in crime Philipp Gauckler and my fantastic past ERA - European Renal Association fellow Anna Matyjek. This has been work over the past 6 years!

Missed the PARASOL Scientific Workshop? Learn about the findings on FSGS endpoints American Society of Nephrology #KidneyWk from Laura Mariani, Prof Danny Gale, Abigail Smith, Aliza Thompson, Josh Tarnoff and Christine B. Sethna, MD EdM. Session Friday, poster Saturday eu1.hubs.ly/H0d6WtH0

Congratulations Omid Omid S. Alavijeh ! I’m delighted to see you win this very well deserved award and excited about what will come next in your career!

🎙️ New episode of #KidneyCompass: Dive into the PARASOL Initiative with Laura Mariani & Prof Danny Gale as they explore the potential of proteinuria & GFR as endpoints in #FSGS trials. Watch here: hcplive.com/view/kidney-co… #Nephrology #ClinicalTrials