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🧵#5 The moment is here: our latest study is out in nature! To catch you up: 20 years of investigating DBS for treatment-resistant #depression & we found a 🎯 (SCC), refined precision, gauged long-term efficacy & spotted early signs of recovery. Now, we have exciting news...

Our recent paper asks why DNA repair deficiency lead to different outcomes in different tissues? nature.com/articles/s4146…

Researchers in Canada got most of what they were hoping for in the country’s 2024 federal budget, with a big boost in postgraduate pay and more funding for research and scientific infrastructure go.nature.com/4azQ8Ft

🆕 nature A new type of transgenerational inheritance, the gut microbiome to germline axis, fathers to offspring, as demonstrated in mice nature.com/articles/s4158… EMBL Jamie Hackett @aye7898

Improved detection of DNA replication fork-associated proteins dlvr.it/T6NQ9Q

How does Mcm10 activate an origin of replication? Find the answer in our paper published today in NatureStructMolBiol. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉 rdcu.be/dIdI4 Great collaboration with Marta, Allie and John from John Diffley The Crick

New scEdU-seq method developed by Alexander van Oudenaarden group measures DNAreplication speed in individual cells & may provide new insights into DNAreplication, embryonic development & cancer. hubrecht.eu/method-dna-rep… Jeroen van den Berg vincentvB Sergio Perez Acebron Anchel de Jaime-Soguero Marcel van Vugt Rinskje

New preprint! 🧬🖥️ With the Johannes Walter, we created a predictome of nucleosome acidic patch binders using AlphaFold. Our approach identified both known and novel acidic patch interactors, opening new avenues for chromatin research. Check it out: biorxiv.org/content/10.110… (1/3)

Very happy to have this out! In this study we show that the DNA modification, 5hmC, increases over bodies of tissue-specific genes in the aging liver and serves a function different from DNA methylation. Congrats James Occean! nature.com/articles/s4146…

SHOCKED THE WORLD. 🥇 Canada's men's 4x100m relay team claims the gold medal in Paris! 🇨🇦 #TeamCanada | #Paris2024 | Radio-Canada Sports

Nearly 40% of professional and recreational athletes do not consume enough energy to match their energy expenditure. Such chronic energy deficiency compromises metabolic, physiological, reproductive, bone and mental health. Here is a mouse model of this syndrome. Wu Tsai Human Performance Alliance

Delighted to see our comment published in Nature Genetics where we proposed a model for a dual function of m6A in R-loop regulation nature.com/articles/s4158…. Reik Lab Altos Labs Alexey Ruzov

In vivo DNA replication dynamics unveil aging-dependent replication stress: Cell cell.com/cell/fulltext/…

Primary structure of histone variants and their influence on nucleosome structure #Figure from the #Review by Lee H. Wong Monash University & David J. Tremethick John Curtin School of Medical Research, ANU: Multifunctional histone variants in genome function go.nature.com/4dDLXcI Free to read: rdcu.be/dQO4i

📖 New review in Nature Reviews Cancer on how epigenomic heterogeneity drives tumour evolution! We dive into: Check it out if you're into epigenetics, single-cell tech, or the future of cancer therapy! 📖 nature.com/articles/s4156…

We must rapidly reverse our discovery research funding death spiral. Our future health and wealth depends on a well funded robust scientific research enterprise policyoptions.irpp.org/magazines/octo…. Brad Wouters 🇨🇦 CIHR NSERC / CRSNG André Picard Chrystia Freeland François-Philippe Champagne (FPC) 🇨🇦 Independent Senators Group (ISG)

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert tinyurl.com/setd2