Broad benefits of the COVID-19 pandemic response: Nonpharmaceutical interventions protected the US population from other infectious diseases science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… Science Magazine

Anti-retroviral treatment of HIV infected individuals improves the ex vivo generation of memory-like NK cells linkinghub.elsevier.com/retrieve/pii/S…

A Nature paper shows SARS-CoV-2 mRNA vaccines can sensitize “cold” tumors to ICB; and it’s not antigen-specific. mRNA itself reprograms innate immunity (type I IFN→APCs→CD8⁺ T cells), boosting antitumor responses. 🧬 nature.com/articles/s4158…

Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption ⁦Science Translational Medicine⁩ science.org/doi/10.1126/sc…

Using a multi-step stimulation protocol, a team shows they can convert self-reacting, pathological CD4 T cells into stable antigen-specific regulatory T cells to suppress autoimmunity and treat pemphigus vulgaris in mice. Science Translational Medicine scim.ag/3J9Fixt

Induced proximity-based therapeutic modalities nature.com/articles/s4157… rdcu.be/eOfBH This new Review discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

Using surveillance data from the CDC for notifiable infectious diseases, researchers in Science have made a comprehensive statistical analysis of the indirect impact of the COVID-19 pandemic on a range of infections occurring in the U.S. Learn more: scim.ag/4nyRkP0

Now online! Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans dlvr.it/TP56tT

Plasmacytoid dendritic cells impair HIV-reactive CD8+ T cells in HIV-infected humanized mice and in PBMCs from people living with HIV Science Translational Medicine University of Maryland School of Medicine The University of North Carolina at Chapel Hill science.org/doi/10.1126/sc…

Mechanism for selection and inhibition of an HIV-1 escape virus by T cells and NK cells (TCR- and KIR2DL2-HLA-C*12:02-peptide complexes) nature.com/articles/s4146… Nature Communications Hokkaido University 🇯🇵 University of Oxford 🇬🇧

Vaccine-specific Tfh undergo robust early expansion, sustained proliferation, months-long persistence w/o exhaustion, and functional specialization associated with enhanced germinal centers & humoral immunity Immunity Prof. Shane Crotty La Jolla Institute cell.com/immunity/fullt…

Presented at #TLM25: Tobevibart plus elebsiran and tobevibart alone both lowered HDV RNA and ALT levels. The combination resulted in a high incidence of undetectable HDV RNA and an HBsAg level below 10 IU/ml at week 48. Full SOLSTICE phase 2 trial results:

Limited vaccine-induced CD8+ T cell immunity in HIV-infected immunological nonresponders JCI insight insight.jci.org/articles/view/…

Potent neutralization of Marburg virus by a vaccine-elicited antibody nature HHMI UW Biochemistry The Veesler Lab Vir Biotechnology nature.com/articles/s4158…

Evasion of CARD8 activation during HIV-1 assembly ⁦Science Advances⁩ science.org/doi/10.1126/sc…

Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals go.nature.com/4qX6KiM

Preprint: HTLV-1 oncoprotein HBZ activates IRF7 but interferes with IRF7-IRF3 interaction to stymie IFN response, but IRF7 transcription of STAT5b promotes proliferation contributing to adult T-cell leukemia/lymphoma researchsquare.com/article/rs-758…

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection Nature Communications Stefanie Bader WEHI (Walter and Eliza Hall Institute) nature.com/articles/s4146…