Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration | Nature Neuroscience nature.com/articles/s4159…

Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua medRxiv Katherine Kedzierska Kedzierska Lab Louise Rowntree medrxiv.org/content/10.110…

The Gene Lay Institute of Immunology and Inflammation was founded on a generous gift Brigham and Women's Hospital MassGeneral News & Harvard Medical School. give.brighamandwomens.org/gene-lay-insti…

A new Science Immunology study in mice suggests that bacterial skin infections can imprint eosinophils with innate immune memory and enhance allergic inflammation in the lungs. scim.ag/42iictO

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease nature.com/articles/s4158…

Natural killer cells can tell between healthy and harmful cells based on the molecules that are present on their surface. Researchers have found the specific receptors that allow them to target cancerous and infected cells. elifesciences.org/digests/100218…

Multi-site investigation of gut microbiota in CDKL5 deficiency disorder mouse models: Targeting dysbiosis to improve neurological outcomes dlvr.it/TK5cMd

Blocking Tim-3 Boosts Microglia in Alzheimer’s - neurosciencenews.com/tim3-alzhiemer… via @neurosciencenew

Review Journal of Experimental Medicine Ana Belén Plata Gómez, PhD Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment rupress.org/jem/article/22…

Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation | Nature Communications nature.com/articles/s4146…

A new treatment approach for Alzheimer's is being studied at Mass General Brigham. The research is focused on removing a certain molecule in the brain’s immune cells. Learn more in 7News Boston WHDH: whdh.com/news/researche…

Just out in Science (2025)—a landmark study by Christina Jackson, MD et al. identifies a previously uncharacterized immune cell population in human glioblastoma (GBM), termed early myeloid-derived suppressor cells (E-MDSCs) (Michael Lim, MD , Chetan Bettegowda , Hongkai Ji , Drew Pardoll ). These

Neoadjuvant immune checkpoint therapy: Enabling insights into fundamental human immunology and clinical benefit dlvr.it/TKBk8z

Congratulations Michael Wheeler et al. on this elegant study showing the underlying mechanisms of how psychedelics influence neuroimmune interactions with implications for fear behaviour. Delighted to be able to contribute to this work. nature.com/articles/s4158…

🚨New paper with Xavier Lab Science Magazine on the critical role of 🔁neuroimmune crosstalk in immune defense in the gut! Gene Lay Institute of Immunology & Inflammation Mass General Brigham Research @HarvardMed @BroadInstitute science.org/doi/10.1126/sc…

Fetal Treg cell reprogramming links maternal immunity to neurodevelopment bit.ly/4dMTebt

New review from Natalia Reglero Real, Loïc Rolas, and Sussan Nourshargh Lab explores how #aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic #inflammation. hubs.la/Q03q8nRg0

What a huge effort from grad student Rocky Barilla who was responsible for driving this project. Well done to Rocky & everyone involved.

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion nature.com/articles/s4146…

Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in nature today! Congrats to Brian Andersen and Camilo! nature.com/articles/s4158…