New from Wang, Visscher et al. (incl. me): in the Mexico City Prospective Study, we find that causal, within-family effects explain ~all of the association between indigenous American (IAM) ancestry and height and type-2 diabetes but ~none of the association with education🧵

.Kristin Tsuo, Alicia Martin, & Mark Daly just wrote the best proteomics paper I've read. They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data. Some 🤯 results 1) proteomics predicts quantity & frequency of alcohol consumed

A new #obesity paradox informed by #genetics 266 variants across 205 genomic loci where adiposity-increasing alleles were simultaneously associated with lower cardiometabolic risk nature.com/articles/s4159…

🔗link to the study: medrxiv.org/content/10.110…

p-tau 217 as a stand-alone blood marker establishes risk of Alzheimer's disease in cognitively unimpaired individuals (again) jamanetwork.com/journals/jaman…

Learning the natural history of human disease with generative transformers | Nature nature.com/articles/s4158…

Massive study on the heritability of diseases/traits using a within-family design by Loïc Yengo et al and the 23andMe team medrxiv.org/content/10.110…

Atopic dermatitis, commonly called #eczema, is a chronic inflammatory skin condition with a global prevalence of 2%. This JAMA Insights explores topical treatments and systemic therapies for atopic dermatitis. ja.ma/4mI1BrJ

Nature research paper: Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA go.nature.com/46zRY9L

New study from us looking at how germline cancer risk (estimated through polygenic scores) correlates with survival for patients who develop cancer. Led by postdoc Danielle Kurant + collaboration with 23andme. 🧵:

Population-scale Long-read Sequencing in the All of Us Research Program | medRxiv medrxiv.org/content/10.110…

Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention nature.com/articles/s4158… nature.com/articles/d4158…

Our work on sperm sequencing is now published! See below for: 🧑‍🔬Scientific tweetorial 📰 Accessible articles discussing implications for aging fathers [1/3] nature.com/articles/s4158…

A brief history of what we know about de novo germline mutation in sperm and it's relevance to the paternal age effect in autism. 🧵1/N

New online! Clinical use of polygenic risk scores: current status, barriers and future directions bit.ly/48oQiRD

Integration of genetic evidence to identify approved drug targets biorxiv.org/content/10.110… #biorxiv_genetic

This study shows combining MRI and genomic data (in a polygenic risk score) beats more traditional models in identifying people at risk of cardiovascular disease. In the future, such data will be abundant, and the value of genomics (including rare variants) will be increased.

🚨 The preprint for our GWAS of Alzheimer’s disease (AD) is out Preprint: medrxiv.org/content/10.110… 🧵

"Common Diseases in Clinical Cohorts — Not Always What They Seem" A low-but-not-that-low number of common disease cases are probably mis-diagnosed rare diseases. nejm.org/doi/full/10.10…

Preprint Paper: biorxiv.org/content/10.110… Github: github.com/23andMe/PRSfor… Looking forward to sharing in San Diego at NeurIPS 2025