A year ago in Nature Biotechnology, Becht et al. argued that UMAP preserved global structure better than t-SNE. Now George C. Linderman and me wrote a comment saying that their results were entirely due to the different initialization choices: biorxiv.org/content/10.110…. Thread. (1/n)

Step 1: have a crazy idea for a new single cell analysis modality; Step2: light >$100k on fire developing new reagents; Step 3: revisit fundamental processes in human immune cell biology and learn something new...really cool application of #MIBI & #CyTOF

Efficacy, immunogenicity, and safety of an oral influenza vaccine: a placebo-controlled and active-controlled phase 2 human challenge study thelancet.com/journals/lanin…

We don’t pretend to be experts in rheumatology, but the strategies reviewed here broadly apply to human immune monitoring in translational research.

Interdisciplinary teams of computer scientists and biologists better validate their models and publish higher impact articles. Nature Machine Intelligence nature.com/articles/s4225…

Rethinking #Mucosal_Antibody Responses | IgG in the neonatal gut mucosa | Andrea Cerutti Icahn School of Medicine at Mount Sinai Nature Rev Immunol buff.ly/39lTMm6

Proud to be recognized and to be in such good company. #innovators #mibi #tissueimaging #drugdiscovery #immunooncology

Tyler Berzin MD, FASGE BIDMC Of the 6 randomized trials of #AI in medicine published to date, 5 are in #gastroenterology, using real-time machine vision during endoscopy. All of these were conducted in China.

Today we are sharing a research protocol for SHERLOCK-based COVID-19 #coronavirus detection, and hope it will help others who are working to combat the outbreak. We will continue to update this as we make further progress: static1.squarespace.com/static/5b7c640…

DNA (blue) and the endoplasmic reticulum (yellow) in a cancer cell starting at the bottom of the nucleus and moving up in Z. Notice the "tunnels" in the nucleus with endoplasmic retilculum on the cytoplasmic side and chromatin on the nuclear side. #CellBiology #Microscopy

We have a fully-funded postdoc position available at the NIH to work on this beautiful system. If you're interested in cell migration, mechanics, cell-cell signaling, imaging, and quantitative image analysis in a collaborative environment, DM me for info. #zebrafishjobs

An immune-cell signature of #Bacterial_Sepsis | Nir Hacohen Broad Institute Nature Medicine buff.ly/2SGXam9

Cell-type-specific signaling networks in heterocellular organoids | Nature Methods nature.com/articles/s4159… #cytofpub Congrats Chris Tape fantastic data!!

The #SingleCell #PathologyLandscape of #BreastCancer | cellular neighbourhoods and interaction networks | Bernd Bodenmiller University of Zurich nature buff.ly/2REsqAo

#2020_ReCap_Feb | #Inflammatory_Bowel_Disease | Pathway paradigms revealed from the genetics | Ramnik Xavier Broad Institute nature buff.ly/2I6VBaU

nature.com/articles/s4301…

Incredible perspective of the universe! #science #Earth HT @evankirstel Paula Piccard Harold Sinnott 📲 Spiros Margaris Michael Fisher Terence Mills Learn as if you will live forever @Droit_IA Dimitris Ioannides ipfconline Sébastien Bourguignon Eric Gaubert Yann Marchand Olivier Laborde#CES2025 #Peace 🇫🇷🇪🇺🇺🇦 Eric T. Nicolas Babin Helene Li ✨🍀💜 HealthIT Policy

#Trained_Immunity and Tolerance | Central and peripheral trained immunity | Eicke Latz Rheinische Friedrich-Wilhelms-Universität Bonn Nature Rev Immunol buff.ly/2IqJ7el

Multiplexed #SingleCell_Morphometry | Maps for hematopathology diagnostics | Sean Bendall Stanford University Nature Medicine buff.ly/38QCb52