Check out my new work with Frank Noe where we answer if the structure of different protein conformations really can be predicted. nature.com/articles/s4146… Also try the Colab to see if your protein has different conformations: colab.research.google.com/github/patrick…

Structure prediction of alternative protein conformations | Nature Communications - Cfold, a structure prediction model designed to predict alternative protein conformations. - Train AF2 without the Template Track and focus on MSAs and coevolutionary signals - Predict different

Well well we'll... Looks like my idea to make chiral photons for assym photo. cat. Isn't that crazy now is it?!?!?!

I’m overjoyed to announce that my K99/R00 proposal has been funded by The National Institute on Aging (NIA) as of today!! I am very excited about the project which is a collaboration with Lehtinen Lab to study the blood-CSF barrier with new analytical tools I’ve developed in the Gygi Lab. Feeling grateful!!

Nitrogen-to-functionalized carbon atom transmutation of pyridine by ⁦Glorius Group⁩ at the U. of Muenster ⁦Chemical Science⁩ pubs.rsc.org/en/content/art…

Another molecular glue at #EFMCISMC24: Novartis #NLRP3 inhibitor DFV890 stabilizing an inactive conformation. Also another example for a non-standard sulfur(VI)-functional group in a drug candidate. No, not a sulfoximine… EFMC

Proteomics Turns 30! It is thirty years since Prof. Marc Wilkins (then an early career researcher) introduced the term "proteomics" at the International Meeting on "2D Electrophoresis: From Protein Maps to Genomes" in Sienna (Italy). #proteomics

It's giving Woodward

🚨New bioRxiv from the Amgen 🧪🔬🧬 Induced Proximity group. Here we introduce LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation. 🧵 biorxiv.org/content/10.110…

Statisically, if a fragment in your library has a carboxylic acid, basic amine (2' or 3') or an alcohol (not phenols) it will form a H-bond with your target. How does your fragment library look like?pubs.acs.org/doi/10.1021/ac…

We are happy to share our new preprint bioRxiv "Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics" led by Kheewoong Baek and Rebecca Metivier of Fischer Lab biorxiv.org/content/10.110…

Excited our final version of Christine Isadora Ng's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. Sarafan ChEM-H Stanford Chemistry nature.com/articles/s4158…

Thrilled to share that, together with my colleagues Centre for Targeted Protein Degradation and collaborators Boehringer Ingelheim, we report Science Magazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/sc…

please clap, this took me 6 hours to make #r #newbie

Simple, Enantiocontrolled Azetidine Library Synthesis via Strain Release Functionalization of 1-Azabicyclobutanes. A fantastic collaboration with the Cravatt lab. A simple, modular, programmable approach to access complex stereopure azetidines through strain-release

Excited to share a new preprint bit.ly/4gzqbJz: we find a molecular glue degrader working via a CRBN lookalike, YPEL5 (a subunit of the non-cullin CTLH/GID E3 ligase). More surprises - the glue is charged and metabolically activated to engage a basic groove on the ligase

My toxic trait is always getting a hot coffee no matter how hot I am/the weather is