long time no see... ...

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Fructose help a tyrant to victimize his subjects. nature.com/articles/s4158… null

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape dlvr.it/SC1JYX

I am grateful to my research team and colleagues ⁦Salk Institute⁩, my collaborators throughout the world, scientists and clinicians who have been rigorously testing the the power of an optimum circadian rhythm in fighting #diabetes. #circadiandiabetescode on sale now.

A chemical from grape seeds can reduce senescent cells and increase healthy lifespan in mice. nature.com/articles/s4225…

NEW ISSUE!: Featuring work from Vila et al. discovering that STING regulates polyunsaturated fatty acid (PUFA) metabolism, and in turn, PUFAs inhibit STING-dependent inflammation. cell.com/cell-metabolis…

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist dlvr.it/SGZpRv

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming #Altoslabs Altos Labs biorxiv.org/content/10.110…

Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction dlvr.it/SJL4Y1

How do dietary glucose and fat signal to the brain to alter feeding behavior? Revisit this exciting paper from AmberAlhadeff's Lab to find out! #gutbrainaxis #diet #macros #CellMet1YearAgo #OpenAccess Monell Center

We will not see the real data in this #TRE paper. Because #NEJM allowed the authors not share any data. Terrible data sharing policy at #NEJM. nejm.org/doi/full/10.10…

Very creative way of studying anatomy

This month’s imaginative Cancer Cell cover: The Monkey King (NK cells) recognizes & tries to kill the White Bone Demon (CTCs), who is disguised as a girl. However, the White Bone Demon pretends to be innocent & convinces Tripitaka (platelets) & Pigsy (HLA-E) to protect it.

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis dlvr.it/SktDbk

Our latest preprint led by FCWEI - organismal lifespan extension is shown to be separable from reproduction limitations in the context of dietary methionine. We further investigate the underlying metabolism of the phenomenon. researchsquare.com/article/rs-303…

Online now! Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans dlvr.it/T3PMhs

Our study now published Nature Aging - we show that the tradeoff between lifespan extension and reduced reproduction can be uncoupled by modifying die. We considered methionine restriction as example. Congrats FCWEI and everyone else who helped 🎉. nature.com/articles/s4358…

Online now! FCWEI et al. show that supplementing folic acid during methionine restriction in flies mitigates the decline in fertility while retaining the intervention’s life-extending benefits. Jason Locasale (rdcu.be/dPiC5) doi.org/10.1038/s43587…