If you attend one scientific meeting next year, do not miss the joint Keystone Targeted Protein Degradation and Proximity Therapeutics, January 21-24, 2024. Promises to be a fireworks display of disease biology, chemical solutions and rising investigational agents. Bring your…

We present the structure of BIRC6, an essential Inhibitor of Apoptosis protein (IAP) and hybrid E2/E3 enzyme. IAPs bind & inhibit caspases, and this inhibitory action is relieved by binding of Smac.

biorxiv.org/cgi/content/sh…

So grateful to receive generous support from Damon Runyon Cancer Research Foundation both during my postdoc and when I start my independent group❤️ Can’t wait to continue my research in engineering new proteins to study cancer biology Harvard Med BCMP Dana-Farber Chemical Biology Program. Lab officially opens in less than one month!!!

If you missed my talk earlier, we are doing a community call for degraders (glues/bifunctionals) to expand mapping of the degradable proteome.
You send us degrader, we return global proteomics data (for free).
If interested, please follow the link to the submission form attached

We solved the structure of HUWE1. Looks familiar..

Preprint here: biorxiv.org/content/10.110…

Thank you to Fischer Lab and DF/HCC for hosting me today in their #ConnectScience series. It is inspiring to see how scientific communication continues despite this awful pandemic.

Excited about this event - our speakers include Matthew Bogyo, @katecarroll_lab, Cheryl Arrowsmith, Alessio Ciulli, Devlin Lab, Anna Greka, Giulio Superti-Furga, KaelinLab, Jen, Amanda Hargrove, christina woo! We built time for panel discussion and posters! Join us!!! #TranslationalChemBio20

Thrilled to share that my F99/K00 grant proposal has been officially funded by National Cancer Institute NIH. So grateful for my mentors - Eric & Nathanael, and all collaborators and lab mates who helped and supported me along the way!

As an immunologist, I’m fortunate to have known Tony Fauci for 40 years and have the highest regard for his skill, knowledge, judgment, commitment and character. We need his leadership, and his clear-eyed assessments and advice about the COVID-19 pandemic. Lives depend on it.

The kinase inhibitor CR8 is a molecular glue degrader that selectively depletes cyclin K. CDK12 acts as a glue-induced substrate receptor. We are very excited to share our new story in collaboration with the Ebert lab Mikołaj Słabicki 🇺🇦 Zuzanna Kozicka Georg Petzold go.nature.com/2AALQS5 @nature

(Free) registration is now open for the 5th New England cryo-EM symposium at Harvard Medical School on April 27! cellbio.med.harvard.edu/5th-new-englan…

if you've been wanting to run Rosetta via a Jupyter notebook, install using Conda, or run your design/prediction jobs using cloud compute, check out our newest tools article in Protein Science:
doi.org/10.1002/pro.37…

Did you have your morning DCAF15 already? With E7820/indisulam/tasisulam #tpd #proteindegradation T. Faust @HojongYoon Katherine A Donovan Fischer Lab

DFCI Center for Protein Degradation is looking for PhD level scientists with backgrounds in:
-Immune oncology
-Animal models
-Cellular and Biochemical assays
-Rosetta Modeling
For more information: cpd.dana-farber.org/join-us.html

The Mark Foundation for Cancer Research announces the #EmergingLeaderAwards , 8 grants to promising early career scientists for projects aimed at addressing substantially unmet needs in cancer risk prediction, prevention, detection, & treatment bit.ly/2QodiEK #ConceptsToCures

Dana-Farber (Dana-Farber Chemical Biology Program, Fischer Lab) and Deerfield Management to create a Center for Protein Degradation, which will interrogate and advance a large portfolio of advanced protein degrader targets while creating a next-gen protein degrader platform: ms.spr.ly/6017rC0PX

Wondering how we deliver the search results at useKit.com ? Read the blog about our search implementation - bit.ly/nRO7Tm

E-Mail sent out to our testing users to try out the new useKit features and giving feedback. Thanks to all our testers. ^NR

20 Minuten Online - «Google Wave wollte zu viel auf einmal» - Webpage 20min.ch/digital/webpag…

http://bit.ly/46REIN